Effect of gamma radiation on polyvinylpyrrolidone hydrogels
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2017
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
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Polyvinylpyrrolidone (PVP) hydrogels have been investigated as drug delivery matrices for the treatment of wounds, such as
cutaneous leishmaniasis, and matrices with silver nanoparticles for chronic wounds and burns. The preparation of such hydrogels
can occur by various cross-linking methods, such as gamma, chemical, physical, among others. The most feasible for wound
dressings is gamma irradiation from cobalt-60, because gamma irradiation simultaneously promotes crosslinking and sterilization,
leaving the wound dressing ready for use. The objective of this work was to investigate the effect on physico- chemical properties
of gamma radiation on PVP hydrogel according to the radiation absorbed dose variation. The PVP hydrogels were irradiated with
doses of 5, 15, 25, 35, 45, 55, 65, 75 and 95kGy at dose rate of 5 kGy/h and characterized by swelling, thermogravimetric and
mechanical analysis. Results shown a favorable dose range window for processing of these hydrogels related to the application.
The results showed that mechanical strength was affected at doses starting at 25 kGy.
Como referenciar
OLIVEIRA, M.J.A.; VASQUEZ, P.A.S.; ALCANTARA, M.T.S.; MUNHOZ, M.M.L.; LUGAO, A.B. Effect of gamma radiation on polyvinylpyrrolidone hydrogels. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 22-27, 2017, Belo Horizonte, MG. Proceedings... Rio de Janeiro, RJ: Associação Brasileira de Energia Nuclear, 2017. Disponível em: http://repositorio.ipen.br/handle/123456789/28349. Acesso em: 15 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.