A tiered approach to assess effects of diclofenac on the brown mussel Perna perna
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2018
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Pharmaceutical discharges into the aquatic ecosystem are of environmental concern and sewage treatment
plants (STPs) have been pointed out as the major source of these compounds to coastal zones,
where oceanic disposal of sewage occurs through submarine outfalls. Diclofenac (DCF) is one of the most
frequently detected pharmaceuticals in water, but little is known about the effects on marine organisms.
In this study, we employed a tiered approach involving the determination of environmental concentrations
of DCF in marine water and the adverse biological effects for fertilization, embryo-larval
development and biomarker responses of the mussel Perna perna. Results indicate that effects in
fertilization rate and embryo-larval development were found in the order of mg$L 1. However, low
concentrations of DCF (ng$L 1) significantly decreased the lysosomal membrane stability and COX activity,
as well as triggered DNA damage, oxidative stress and changes in antioxidant defenses. Our results
point to an environmental hazard at coastal ecosystems and suggest the need for improvements in the
treatment of domestic wastewater aiming to reduce DCF concentrations, as well as regulation on current
environmental legislation and monitoring of aquatic ecosystems.
Como referenciar
FONTES, MAYANA K.; GUSSO-CHOUERI, PALOMA K.; MARANHO, LUCIANE A.; ABESSA, DENIS M. de S.; MAZUR, WESLEY A.; CAMPOS, BRUNO G. de; GUIMARAES, LUCIANA L.; TOLEDO, MARCOS S. de; LEBRE, DANIEL; MARQUES, JOYCE R.; FELICIO, ANDREIA A.; CESAR, AUGUSTO; ALMEIDA, EDUARDO A.; PEREIRA, CAMILO D.S. A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: a contribution to characterize the hazard. Water Research, v. 132, p. 361-370, 2018. DOI: 10.1016/j.watres.2017.12.077. Disponível em: http://repositorio.ipen.br/handle/123456789/28948. Acesso em: 14 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.