Parameters for antimicrobial photodynamic therapy on periodontal pocket
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2019
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Photodiagnosis and Photodynamic Therapy
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Background: Antimicrobial photodynamic therapy (aPDT) has been investigated as an adjunctive to periodontal
treatment but the dosimetry parameters adopted have discrepancies and represent a challenge to measure efficacy.
There is a need to understand the clinical parameters required to obtain antimicrobial effects by using
aPDT in periodontal pockets. The aim of this study was to investigate parameters relating to the antimicrobial
effects of photodynamic therapy in periodontal pockets.
Material and methods: This randomized controlled clinical trial included 30 patients with chronic periodontitis.
Three incisors from each patient were selected and randomized for the experimental procedures. Microbiological
evaluations were performed to quantify microorganisms before and after treatments and spectroscopy was used
to identify methylene blue in the pocket. A laser source with emission of radiation at wavelength of ʎ=660 nm
and output radiant power of 100mW was used for 1, 3 and 5 min. One hundred μM methylene blue was used in
aqueous solution and on surfactant vehicle.
Results: The results demonstrated the absence of any antimicrobial effect with aqueous methylene blue-mediated
PDT. On the other hand, methylene blue in the surfactant vehicle produced microbial reduction in the group
irradiated for 5 min (p < 0.05). Spectroscopy showed that surfactant vehicle decreased the dimer peak signal at
610 nm.
Conclusion: Within the parameters used in this study, PDT mediated by methylene blue in a surfactant vehicle
reached significant microbial reduction levels with 5 min of irradiation. The clinical use of PDT may be limited
by factors that reduce the antimicrobial effect. Forms of irradiation and stability of the photosensitizers play an
important role in clinical aPDT.
Como referenciar
ALVARENGA, LETICIA H.; GOMES, ANA C.; CARRIBEIRO, PAMELA; GODOY-MIRANDA, BIANCA; NOSCHESE, GIOVANE; RIBEIRO, MARTHA S.; KATO, ILKA T.; BUSSADORI, SANDRA K.; PAVANI, CHRISTIANE; GERALDO, YHAGO G.E.; SILVA, DANIELA de F.T. da; HORLIANA, ANNA C.R.T.; WAINWRIGHT, MARK; PRATES, RENATO A. Parameters for antimicrobial photodynamic therapy on periodontal pocket: randomized clinical trial. Photodiagnosis and Photodynamic Therapy, v. 27, p. 132-136, 2019. DOI: 10.1016/j.pdpdt.2019.05.035. Disponível em: http://repositorio.ipen.br/handle/123456789/30018. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.