Use of pseudoboehmite for drug delivery system of simvastatin
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2019
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BRAZIL MRS MEETING, 18th
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Resumo
Simvastatin is a well known anti-cholesterol drug that is commercially available in
Brazil in various strengths including Simvastatin Tablets, with 10, 20 and 40 mg.
Simvastatin is a drug, which is used for treating patients with
hypercholesterolemia, in order to prevent atherosclerosis, cardiovascular disease,
and stroke1. Today cardiovascular disease is still the leading cause of death
worldwide. It should also be noted that the treatment of cardiovascular diseases
was responsible for just over a third of what the Brazilian federal government
disbursed between the years 2013 and 2016 in the purchase of medicines for the
population. However, the side effects of simvastatin include muscle pain and liver
problems. When diet and exercise are not enough to reduce cholesterol levels,
drugs as simvastatin are the medication prescribed. One problem of simvastatin is
the low solubility. Simvastatin is practically insoluble in water (30 μg/mL), and 0.1
M HCl (60 μg/mL) [1,2,3]. This paper presents pseudoboehmite nanoparticles
synthesized via sol-gel process. The pseudoboehmite were synthesized by an
ethanol/water sol–gel method using aluminum nitrate as precursos and sodium
hydroxide. The pseudoboehmite with simvastatin entrapped was characterized by
X-ray diffraction (XRD), scanning electron microscope (SEM) using secondary
electrons detector and EDS detector, thermal analysis (thermogravimetric
analysis and differential thermal analysis) and Fourier transform infrared
spectrometer (FTIR). The data shows that the simvastatin was incorporated
homogenously in the pseudoboehmite. The Fourier transform infrared analysis
shows that there was no degradation of the drug.
Como referenciar
VICENTE, MARCOS A.A.H.; MUNHOZ JUNIOR, ANTONIO H.; MIRANDA, LEILA F. de; SARMENTO, BRUNO F.C.C.; BERNUSSI, AYRTON; OLIVEIRA, RENE; RIBEIRO, ROBERTO R.; MORAES, DENISON A. Use of pseudoboehmite for drug delivery system of simvastatin. In: BRAZIL MRS MEETING, 18th, September 22-26, 2019, Balneário Camburiú, SC. Abstract... São Carlos, SP: Aptor Software, 2019. p. 687-688. Disponível em: http://repositorio.ipen.br/handle/123456789/31053. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.