Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis
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2020
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Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease
causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized
by severe hypoxemia. Computed tomography (CT), among other imaging techniques,
allows the morphological and quantitative identification of lung lesions during ARDS. This
study aims to identify the onset of malaria-associated ARDS development in an experimental
model by imaging diagnosis. Our results demonstrated that ARDS-developing mice presented
decreased gaseous exchange and pulmonary insufficiency, as shown by the
SPECT/CT technique. The pulmonary aeration disturbance in ARDS-developing mice on
the 5th day post infection was characterized by aerated tissues decrease and nonaerated
tissue accumulation, demonstrating increased vascular permeability and pleural effusion.
The SPECT/CT technique allowed the early diagnosis in the experimental model, as well as
the identification of the pulmonary aeration. Notwithstanding, despite the fact that this study
contributes to better understand lung lesions during malaria-associated ARDS, further imaging
studies are needed.
Como referenciar
QUIRINO, THATYANE de C.; ORTOLAN, LUANA dos S.; SERCUNDES, MICHELLE K.; MARINHO, CLAUDIO R.F.; TURATO, WALTER M.; EPIPHANIO, SABRINA. Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis. PLoS One, v. 15, n. 5, p. 1-18, 2020. DOI: 10.1371/journal.pone.0233864. Disponível em: http://repositorio.ipen.br/handle/123456789/31413. Acesso em: 05 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.