Natural polymer hydrogels with gold nanoparticles for bladder cancer chemotherapy delivery
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2019
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WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th
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The treatment of bladder cancer is done by transurethral resection for tumor removal, followed
by immune or chemotherapy intravesical, according to the stage of the disease. The main
objective of this work was to develop and characterize strategies to increase the residence time
and specificity of chemotherapy through the application of hydrogels for chemotherapy and /or
immunotherapy administration. Natural polymers gellan gum and microcrystalline cellulose were
chosen to prepare the hydrogels as they are already widely used in the biomedical area due to
characteristics such as the absence of toxicity, high biocompatibility, and biodegradability.
Papain-coated gold nanoparticles were added to the gels to promote chemo or
immunotherapeutic permeation. Preliminary stability assays were carried out to evaluate the
compatibility between the polymeric matrices and the gold nanoparticles. The systems were
characterized by Scanning Electron Microscopy, and Fourier Transform Infrared Spectroscopy.
The results allowed the identification of the polymer groups present in the formulations, as well
as the evaluation of the interactions between the hydrogel network and the nanoparticles. The
formulations were suitable for the proposed application.
Como referenciar
LIMA, C.S.A.; VARCA, G.; DE FREITAS, L.F.; VARCA, J.O.; LUGAO, A.B. Natural polymer hydrogels with gold nanoparticles for bladder cancer chemotherapy delivery. In: WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th, October 29-31, 2019, São Paulo, SP. Abstract... p. 127-127. Disponível em: http://repositorio.ipen.br/handle/123456789/31554. Acesso em: 20 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.