The spreading depression propagation
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2021
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Open Journal of Biophysics
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Resumo
At the transition from quiescence to propagating waves recorded in isolated
retinas, a circular electric current closes in the extracellular matrix; this circular
current creates a magnetic torus flow that, when entering quiescent tissue
in front of the wave, recruits elements and when leaving behind, helps to
build the absolute refractory state. The waving magnetic torus is the consequence
of the vortex effect and explains the energy boost that drives propagation.
Methods: We interpret experimental results from intrinsic and extrinsic
fluorescence dyes, voltage, calcium and pH sensitive, optical signals from isolated
retinas, and time series recordings using ion exchange resins: Ca, K, pH,
Na, Cl recorded extracellularly at retinas, cerebellums and cortices coupled to
spreading depression waves. Finally, we checked the ECoG activity, also a
time series, at the transition from after discharges to spreading depression in
rat hippocampus. Results: The integrated assessment of the diversified measurements
led to the realization that the magnetic flow at the wavefront is a
major contributor to the wave propagation mechanisms. This flow couples
mass and charge flows as a swirling torus from excited to quiescent tissue.
Conclusions: An alternative model of the brain is possible, apart from the
classical HH and molecular biology model. Physical chemistry of charged gels
and its flows explains the results. The conceptual framework uses far from
equilibrium thermodynamics.
Como referenciar
LIMA, VERA M.F. de; PEREIRA JUNIOR, ALFREDO; OLIVEIRA, GUILHERME L. de. The spreading depression propagation: how electrochemical patterns distort or create perception. Open Journal of Biophysics, v. 11, n. 2, p. 133-146, 2021. DOI: 10.4236/ojbiphy.2021.112003. Disponível em: http://repositorio.ipen.br/handle/123456789/31942. Acesso em: 15 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.