Optical biopsy and artificial intelligence as a diagnostic tool of smokers
Data
Data de publicação:
2021
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
FÓRUM ON-LINE DE TECNOLOGIAS DA LUZ NA SAÚDE, 2nd
Exportar
Resumo
Background: FT-IR spectroscopy can investigate and detect tissue changes at biochemical levels, the result is obtained quickly, it needs a small sample amount, which can be biofluids. Objective: Compare saliva between smoking and non-smoking patients by FT-IR spectroscopy, as an optical biopsy technique and associate with data processing methods based on artificial intelligence. It will be possible to investigate biochemical changes at the molecular level, and in the future use it as an early diagnosis of oral cancer. Methodology: This study was approved by the Research Ethics Committee, and was conducted using a FT-IR spectroscopy coupled with and attenuated total reflection accessory. Volunteers were divided into three groups, however just 10 patients were analyzed as pilot study. In control group were collected saliva of volunteers who had never tried tobacco (15 spectra from 5 samples). In smoking group patients over 40 years old who smoke more than one pack of cigarettes a day (3 spectra from 1 sample); In sporadic smoking group, patients who smoke sporadically and/or socially (12 spectra from 4 samples). Results: In all groups, the structural components were DNA, RNA, lipids, proteins and Amide. The spectra showed different intensities in the respective structural components mentioned above, so that subtle differences could prove that the saliva of smoking patients has differences with normal patients. Conclusion: Optical biopsy and artificial intelligence could be used in the medical field, it is a safe and label technique, more patients should be analyzed for solid results.
Como referenciar
FERREIRA, MARIA C. de M.S.C.; CASTRO, PEDRO A.A. de; PERALTA, FELIPE da S.; KITAKAWA, DARCIO; ZEZELL, DENISE M.; CARVALHO, LUIS F. das C. e S. de. Optical biopsy and artificial intelligence as a diagnostic tool of smokers: a pilot study. In: FÓRUM ON-LINE DE TECNOLOGIAS DA LUZ NA SAÚDE, 2nd, May 20-22, 2021, Online. Abstract... Campinas, SP: Faculdade São Leopoldo Mandic, 2021. Disponível em: http://repositorio.ipen.br/handle/123456789/32684. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.