Nanodiagnostic tools for mycotoxins detection
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2022
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Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine
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In recent decades, mycotoxin contamination of agricultural food items has garnered considerable attention because to their high acute or chronic toxicity in humans and animals, resulting from consumption and exposure duration to contaminated food or feed. This is exacerbated by the impact of the Covid-19 pandemic, civil wars, and conflicts (e.g., the Russia-Ukraine conflict, Yemen, Ethiopia, Afghanistan, and others), which further strain the food security and nutritional status of the most vulnerable demographic groups, which are predicted to continue to deteriorate due to health and socioeconomic factors. The presence of these mycotoxins in food and animal feed has a negative impact on public health and the economy; consequently, it is crucial to detect and quantify these toxins in agricultural lots. Maintaining food quality and minimizing adverse effects on human and animal health are dependent on early detection. Conventional techniques for detecting mycotoxins include enzyme-linked immunoassay (ELISA), gas chromatography (GC), thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC). Nanomaterial-based sensor technologies provide diverse mitigation methods for quantifying single or multiple analytes, as mycotoxin co-occurrence in a single matrix has become more common. In this chapter, we describe recent advancements in nanodiagnostic techniques that permit multiplex detection of mycotoxins on a single platform. In addition, we discuss certain commercially available lateral flow immunoassay (LFIA) test strips that often use gold nanoparticles (AuNPs) or quantum dots (QDs) as colored labels for signal amplification, as well as some commercial goods with nanoformulations used in agriculture. For the commercialization of nano-based assays (nanosensors), nanodisks (nanoparticles-based artificial sensing), and that may be used as point-of-care testing (POCT) devices for mycotoxin detection, it will be necessary to conduct additional research and make additional investments to overcome the difficulties identified.
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THIPE, VELAPHI C.; MENDES, GIOVANNA de O.A.; ALVES, VICTORIA M.; SOUZA, THAYNA; AJAYI, RACHEL F.; LUGAO, ADEMAR B.; KATTI, KATTESH V. Nanodiagnostic tools for mycotoxins detection. In: LIM, KI-TAEK (ed.); ABD-ELSALAM, KAMEL A. (ed.). Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine. Cham, Switzerland: Springer Nature, 2022. , cap. 15. p. 361-381. DOI: 10.1007/978-3-031-16084-4_15. Disponível em: http://repositorio.ipen.br/handle/123456789/34190. Acesso em: 14 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.