3D element imaging using NSECT for the detection of renal cancer
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2013
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Physics in Medicine and Biology
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This work describes a simulation study investigating the application of neutron
stimulated emission computed tomography (NSECT) for noninvasive 3D
imaging of renal cancer in vivo. Using MCNP5 simulations, we describe a
method of diagnosing renal cancer in the body by mapping the 3D distribution
of elements present in tumors using the NSECT technique. A human phantom
containing the kidneys and other major organs was modeled in MCNP5.
The element composition of each organ was based on values reported in
literature. The two kidneys were modeled to contain elements reported in
renal cell carcinoma (RCC) and healthy kidney tissue. Simulated NSECT
scans were executed to determine the 3D element distribution of the phantom
body. Elements specific to RCC and healthy kidney tissue were then analyzed
to identify the locations of the diseased and healthy kidneys and generate
tomographic images of the tumor. The extent of the RCC lesion inside the
kidney was determined using 3D volume rendering. A similar procedure was
used to generate images of each individual organ in the body. Six isotopes were
studied in this work—32S, 12C, 23Na, 14N, 31P and 39K. The results demonstrated
that through a single NSECT scan performed in vivo, it is possible to identify the
location of the kidneys and other organs within the body, determine the extent of
the tumor within the organ, and to quantify the differences between cancer and
healthy tissue-related isotopes with p 0.05. All of the images demonstrated
appropriate concentration changes between the organs, with some discrepancy
observed in 31P, 39K and 23Na. The discrepancies were likely due to the low
concentration of the elements in the tissue that were below the current detection
sensitivity of the NSECT technique.
Como referenciar
VIANA, R.S.; AGASTHYA, G.A.; YORIYAZ, H.; KAPADIA, A.J. 3D element imaging using NSECT for the detection of renal cancer: a simulation study in MCNP. Physics in Medicine and Biology, v. 58, n. 17, p. 5867-5883, 2013. DOI: 10.1088/0031-9155/58/17/5867. Disponível em: http://repositorio.ipen.br/handle/123456789/8470. Acesso em: 04 May 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.