Favorable effects of ezetimibe alone or in association with simvastatin on the removal from plasma of chylomicrons in coronary heart disease subjects
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2014
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Atherosclerosis
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Objective: Reductions on the clearance from plasma of chylomicrons are associated with atherosclerosis.
Statins improve the removal from plasma of chylomicrons in a dose dependent manner. There is controversy whether ezetimibe modifies the plasma clearance of chylomicrons. Effects of ezetimibe alone or
in combination with simvastatin were compared with low and high dose of the latter, upon the kinetics
of a chylomicron-like emulsion in coronary heart disease (CHD) patients.
Methods: 25 CHD patients were randomized for treatment with ezetimibe 10 mg (group 1) or simvastatin 20 mg (group 2) with progression to ezetimibe รพ simvastatin 10/20 mg or simvastatin 80 mg,
respectively. Kinetic studies were performed at baseline and after each treatment period of 6 weeks. The
fractional catabolic rates (FCR) of the emulsion labeled with 14C-CE and 3
H-TG, that represent respectively chylomicron remnant and triglyceride removal, were calculated. Comparisons were made by
ANOVA.
Results: The 14CE-FCR in group 1 were 0.005 0.004, 0.011 0.008 and 0.018 0.005 min1 and in
group 2 were 0.004 0.003, 0.011 0.008 and 0.019 0.007 min1 respectively at baseline, after 6 and
12 weeks (p < 0.05 vs. baseline, and 6 vs. 12 weeks). The 3
H-TG-FCR in group 1 were 0.017 0.011,
0.024 0.011 and 0.042 0.013 min1 and in group 2 were 0.016 0.009, 0.022 0.009 and
0.037 0.012 min1 at baseline, after 6 and 12 weeks (p < 0.05 vs. baseline, and 6 vs. 12 weeks). There
were no differences between groups in time.
Conclusion: Both treatments increased similarly the removal from plasma of chylomicron and remnants
in CHD patients.
Como referenciar
MANGILI, OTAVIO C.; GAGLIARDI, ANA C.M.; MANGILI, LEONARDO C.; MESQUITA, CARLOS H.; CESAR, LUIZ A.M.; TANAKA, AKIRA; SCHAEFER, ERNST J.; MARANHAO, RAUL C.; SANTOS, RAUL D. Favorable effects of ezetimibe alone or in association with simvastatin on the removal from plasma of chylomicrons in coronary heart disease subjects. Atherosclerosis, v. 233, n. 1, p. 319-325, 2014. DOI: 10.1016/j.atherosclerosis.2013.12.008. Disponรญvel em: http://repositorio.ipen.br/handle/123456789/8944. Acesso em: 10 May 2024.
Esta referรชncia รฉ gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificaรงรฃo final e ajustes caso necessรกrio.