Dose rate by distance for Au-198 nanoparticles in water

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dc.contributor.authorANGELOCCI, L.V.
dc.contributor.authorSGRIGNOLI, S.S.
dc.contributor.authorSOUZA, C.D.
dc.contributor.authorTEODORO, L.E.H.
dc.contributor.authorZEITUNI, C.A.
dc.contributor.authorROSTELATO, M.E.C.M.
dc.coverageInternacional
dc.date.accessioned2025-02-21T19:26:09Z
dc.date.available2025-02-21T19:26:09Z
dc.date.issued2024
dc.description.abstractPurpose: To evaluate dose as a function of depth in water medium by a source of Au-198 nanoparticles, both as a point source and as homogeneously distributed over a volume representing a prostate tumor. Dose over an unidirectional axis was estimated and presented according to distance from the source, highlighting nearby organs at risk. The aim of the work is the first step in the dosimetric characterization of a new source for nanobrachytherapy under development, consisting of Au-198 nanoparticles injected directly in tumoral mass. Methods: Simulations were carried using MCNP6.2 code by Los Alamos National Laboratory. Four different simulations were realized, for two different source configurations (point source and 0.4 cm radius spherical source, modeling a prostate tumor) each considering two different components for the dose (beta emission and photon (gamma/x-ray) emission from the source). Medium considered was infinite water homogeneous. Results: Dose curve as a function of distance from the source was evaluated and allowed a first estimative of dose at points of interest for treatment with a new nanobrachytehrapy source. Point source results are valuable for future extrapolation for complex tumor/organs geometry. Prostate tumor model presents data that allows to estimate dose at center of tumor, borders of tumor, and at other organs nearby, such as rectum and bladder. Conclusion: Being a beta-emitter, Au-198 shows a high deposition of energy near the source, with doses falling significantly with distance from the source. However, due to gamma and x-ray emission from the source, as well as secondary radiation originating from the beta particles, not-negligible dose was scored at significant distance. This quantitative study will be relevant for posterior dosimetry of more complex cases as well to develop protocols for dosimetry and clinical use, as nanobrachytherapy (with nanoparticles as sources) is a relatively new field with few specific works published.
dc.format.extent7715-7716
dc.identifier.citationANGELOCCI, L.V.; SGRIGNOLI, S.S.; SOUZA, C.D.; TEODORO, L.E.H.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M. Dose rate by distance for Au-198 nanoparticles in water. <b>Medical Physics</b>, v. 51, n. 10, p. 7715-7716, 2024. DOI: <a href="https://dx.doi.org/10.1002/mp.17457">10.1002/mp.17457</a>. Disponível em: https://repositorio.ipen.br/handle/123456789/49087.
dc.identifier.doi10.1002/mp.17457
dc.identifier.fasciculo10
dc.identifier.issn0094-2405
dc.identifier.orcidhttp://orcid.org/0000-0003-1335-8864
dc.identifier.orcidhttps://orcid.org/0000-0002-7303-6720
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.percentilfi77.7
dc.identifier.percentilfiCiteScore80.00
dc.identifier.urihttps://repositorio.ipen.br/handle/123456789/49087
dc.identifier.vol51
dc.relation.ispartofMedical Physics
dc.rightsopenAccess
dc.sourceAnnual Meeting of the American Association of Physicists in Medicine (AAPM), July 21-25, 2024, Los Angeles, CA, USA
dc.titleDose rate by distance for Au-198 nanoparticles in water
dc.typeResumos em periódicos
dspace.entity.typePublication
ipen.autorLUCAS VERDI ANGELOCCI
ipen.autorSABRINA SPIGAROLI SGRIGNOLI
ipen.autorCARLA DARUICH DE SOUZA
ipen.autorLARA EL HAJJ TEODORO
ipen.autorCARLOS ALBERTO ZEITUNI
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.codigoautor12698
ipen.codigoautor16160
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ipen.codigoautor14897
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ipen.codigoautor7
ipen.contributor.ipenauthorLUCAS VERDI ANGELOCCI
ipen.contributor.ipenauthorSABRINA SPIGAROLI SGRIGNOLI
ipen.contributor.ipenauthorCARLA DARUICH DE SOUZA
ipen.contributor.ipenauthorLARA EL HAJJ TEODORO
ipen.contributor.ipenauthorCARLOS ALBERTO ZEITUNI
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.identifier.fi3.2
ipen.identifier.fiCiteScore6.8
ipen.identifier.ipendoc31144
ipen.identifier.iwosWoS
ipen.range.fi3.000 - 4.499
ipen.range.percentilfi75.00 - 100.00
ipen.type.genreResumo
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sigepi.autor.atividadeLUCAS VERDI ANGELOCCI:12698:230:S
sigepi.autor.atividadeSABRINA SPIGAROLI SGRIGNOLI:16160:-1:N
sigepi.autor.atividadeCARLA DARUICH DE SOUZA:7717:230:N
sigepi.autor.atividadeLARA EL HAJJ TEODORO:14897:230:N
sigepi.autor.atividadeCARLOS ALBERTO ZEITUNI:944:230:N
sigepi.autor.atividadeMARIA ELISA CHUERY MARTINS ROSTELATO:7:230:N
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