Submissões Recentes
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Evaluation of thermal stability of silicone rubber for brachytherapy applications
2025 - TEODORO, LARA E. H.; TALACIMON, CRISTHIAN F.; BURIN, ANA L.; SILVA, ANA C. K. S.; RIGO, MARIA E. Z.; MEDEIROS, ILCA M. M. A.; SGRIGNOLI, SABRINA S.; RODRIGUES, PRISCILA S.; LEAL, DAVID A. U.; ROSA, GIOVANNA M.; MIRANDA, SILAS L. P.; TAVARES, PAULO V. S.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E. C. M.
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Tenebrio molitor-derived ingredients in obesity management
2025 - RAGOZZINO-PAULINO, PIETRO; COCATO, MARIA L.; SARKIS, JORGE E. de S.
Pharmacological strategies for obesity management have advanced rapidly with GLP-1 and dual GLP-1/GIP agonists. Despite their clinical efficacy, these treatments remain costly, require ongoing use, and can cause adverse events—highlighting the need for complementary, safe, and sustainable options. Tenebrio molitor (yellow mealworm) has been investigated as a source of bioactive peptides and lipids with preclinical signals relevant to obesity (metabolic and inflammatory pathways) and microbiota modulation. This perspective consolidates species-specific mechanistic pathways for T. molitor and synthesizes them into a single translational framework with implications for nutraceutical development. Evidence from in vitro and in vivo animal models indicates that derivatives—including whole/defatted flours, protein hydrolysates, lipid extracts, and oil fractions—can suppress adipogenesis, improve lipid handling, attenuate inflammatory signaling, regulate appetite, and induce beneficial gut-microbiota shifts; collectively, these effects align with modulation of PPARα/AMPK/MAPK signaling, reduced low-grade inflammation, and engagement of gut–brain axis satiety mechanisms. Human trials with standardized T. molitor formulations remain limited, reinforcing the need for randomized studies with defined compositions and metabolic endpoints. Translational use also requires consideration of allergenicity (arthropod pan-allergens) and heterogeneous regulatory frameworks, emphasizing labeling and ingredient specification. Novelty: This perspective delivers a species-specific, mechanism-first framework for Tenebrio molitor that unites scientific, technological, and regulatory dimensions. It provides the first integrated mechanistic map linking ingredient classes (flours, hydrolysates, fermented extracts, oils) to pathways and metabolic outcomes, paired with a curated evidence table and concise, practice-oriented safety and regulatory guidance. By stating explicit study-selection criteria and emphasizing standardization of derivatives, dosage/delivery, and long-term safety, the paper advances functional food science with a clear translational scaffold for nutraceutical development and future targeted-outcome evaluations.
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Evaluation of the technical feasibility of commercial compatibilizers for multilayer film recycling
2025 - ZILIANI, MARCOS R.; SILVA, LEONARDO G. de A.
This study aims to evaluate major commercial compatibilizers for the recycling of multilayer films. Samples were sourced from post-consumer and post-industrial materials and processed using standard industrial equipment, including agglomerators, granulators (knife mills), and an extruder for compatibilizer incorporation. The materials were subsequently tested according to the criteria established by ASTM D648 (Standard Test Method for Deflection Temperature of Plastics Under Flexural Load in the Edgewise Position) and ASTM D6110 (Standard Test Method for Determining the Charpy Impact Resistance of Notched Specimens of Plastics). Compatibilizing agents were added at the same concentration and using a consistent incorporation methodology to produce pellets, which were then injection-molded into test specimens for evaluation. The raw material was initially characterized using Differential Scanning Calorimetry (DSC) and Thermogravimetric Analysis (TGA). These techniques were used to assess the basic composition of the material under study, as well as its thermal decomposition behavior and inorganic residue content. Overall, the resulting specimens tested using HDT and Charpy impact tests showed significant changes in certain mechanical and thermal properties, while others remained virtually unchanged. The results indicate that specific compatibilizers demonstrated great potential for the recycling of multilayer films.
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Effects of ionizing radiation on the molecular structure of polyethylene
2025 - ZERBATO, TANIA M. S.; SILVA, LEONARDO G. de A.