Filmes poliméricos a base PHB e PHB-V utilizados como sistemas de liberação controlada de hormônio de crescimento humano recombinante
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2005
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CONGRESSO BRASILEIRO DE POLIMEROS, 8.
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Due to its short half-life and necessity for daily subcutaneous injections, recombinant human growth hormone (rhGH)
would best be administered in a controlled release formulation. One approach to this is the use of potentially
biodegradable films implants based on both polyesters poly(3-hydroxybutyrate) (PHB) and poly(hydroxybutyrate-covalerate) (PHB-V). These polymers are being explored in the health area due to their hydrolytic degradation that occurs
by surface erosion, which make them attractive materials for controlled release applications. PHB and PHB-V films
were designed using the solvent casting technique. Two different amounts of PEG, 5% and 65% (w/w), were introduced
in films formulations to investigate its leaching and plasticizing effect. Morphologic analysis by Scanning Electron
Microscopy (SEM) showed the presence of porosity for films with 67% (w/w) PEG. In this work, some investigations
on the in vitro release of rhGH entrapped in the films, are reported. The kinetics of rhGH release from matrices were
examined and the results indicate that the release practically occurs in the first 2 hours.
Como referenciar
MARTELLINI, F.; RIBELA, M.T.C.P.; BARTOLINI, P.; CARENZA, M.; MEI, L.H.I. Filmes polimericos a base PHB e PHB-V utilizados como sistemas de liberacao controlada de hormonio de crescimento humano recombinante. In: CONGRESSO BRASILEIRO DE POLIMEROS, 8., 6-10 nov, 2005, Aguas de Lindoia, SP. Anais... Disponível em: http://repositorio.ipen.br/handle/123456789/15620. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.