Treating metabolic sundrome's metaflammation with low level light therapy: preliminary results

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dc.contributor.authorYOSHIMURA, TANIA M.
dc.contributor.authorKATO, ILKA T.
dc.contributor.authorDEANA, ALESSANDRO M.
dc.contributor.authorRIBEIRO, MARTHA S.
dc.contributor.editorHAMBLIN, MICHAEL R.
dc.contributor.editorCARROLL, JAMES D.
dc.contributor.editorARANY, PRAVEEN
dc.coverageInternacionalpt_BR
dc.creator.eventoMECHANISMS FOR LOW-LIGHT THERAPY, 9thpt_BR
dc.date.accessioned2015-06-10T13:36:13Z
dc.date.available2015-06-10T13:36:13Z
dc.date.eventoFebruary 1, 2014pt_BR
dc.description.abstractMetabolic syndrome comprises a constellation of morbidities such as insulin resistance, hyperinsulinemia, atherogenic dyslipidemia, dysglycemia and obesity (especially abdominal). Metabolic alterations are observed in major insulin target organs, increasing the risk of cardiovascular diseases, type-2 diabetes and therefore mortality. Tissue alterations are characterized by immune cells infiltrates (especially activated macrophages). Released inflammatory mediators such as TNF-α induce chronic inflammation in subjects with metabolic syndrome, since inflammatory pathways are activated in the neighboring cells. The intra-abdominal adipose tissue appears to be of particular importance in the onset of the inflammatory state, and strategies contributing to modulate the inflammatory process within this adipose tissue can mitigate the metabolic syndrome consequences. Considering the low level light therapy (LLLT) recognized benefits in inflammatory conditions, we hypothesized this therapeutic approach could promote positive effects in modulating the inflammatory state of metabolic syndrome. That being the scope of this study, male C57BL/6 mice were submitted to a high-fat/high-fructose diet among 8 weeks to induce metabolic syndrome. Animals were then irradiated on the abdominal region during 21 days using an 850 nm LED (6 sessions, 300 seconds per session, 60 mW output power, ~6 J/cm² fluence, ~19 mW/cm² fluence rate). Before and during treatment, blood was sampled either from the retroorbital plexus or from tail puncture for glucose, total cholesterol and triglycerides analysis. So far our results indicate no alterations on these metabolic parameters after LLLT. For further investigations, blood was collected for plasma inflammatory cytokine quantification and fresh ex vivo samples of liver and intra-abdominal adipose tissue were harvested for immunohistochemistry purposes.
dc.event.siglaSPIEpt_BR
dc.format.extent89320J-1 - 89320J-9pt_BR
dc.identifier.citationYOSHIMURA, TANIA M.; KATO, ILKA T.; DEANA, ALESSANDRO M.; RIBEIRO, MARTHA S. Treating metabolic sundrome's metaflammation with low level light therapy: preliminary results. In: HAMBLIN, MICHAEL R. (ed.); CARROLL, JAMES D. (ed.); ARANY, PRAVEEN (ed.). In: MECHANISMS FOR LOW-LIGHT THERAPY, 9th, February 1, 2014, San Francisco, California, United States. <b>Proceedings...</b> p. 89320J-1 - 89320J-9. (SPIE Proceedings Series, 8932). DOI: <a href="https://dx.doi.org/10.1117/12.2040901">10.1117/12.2040901</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/23711.
dc.identifier.doi10.1117/12.2040901
dc.identifier.orcidhttps://orcid.org/0000-0002-4203-1134
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/23711
dc.local.eventoSan Francisco, California, United Statespt_BR
dc.publisherSociety of Photho-optical Instrumentation Engineerspt_BR
dc.relation.ispartofseriesSPIE Proceedings Series, 8932
dc.rightsopenAccesspt_BR
dc.subjectdiabetes mellitus
dc.subjectcholesterol
dc.subjecttriglycerides
dc.subjectmetabolic diseases
dc.subjecttherapy
dc.titleTreating metabolic sundrome's metaflammation with low level light therapy: preliminary resultspt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorMARTHA SIMOES RIBEIRO
ipen.autorALESSANDRO MELO DE ANA
ipen.autorILKA TIEMY KATO
ipen.autorTANIA MATEUS YOSHIMURA
ipen.codigoautor574
ipen.codigoautor3423
ipen.codigoautor3089
ipen.codigoautor10230
ipen.contributor.ipenauthorMARTHA SIMOES RIBEIRO
ipen.contributor.ipenauthorALESSANDRO MELO DE ANA
ipen.contributor.ipenauthorILKA TIEMY KATO
ipen.contributor.ipenauthorTANIA MATEUS YOSHIMURA
ipen.date.recebimento15-06pt_BR
ipen.event.datapadronizada2014pt_BR
ipen.identifier.ipendoc20751pt_BR
ipen.identifier.ods3
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
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relation.isAuthorOfPublication9de5f11a-82fa-4cc7-a353-6ef7475e2dbb
relation.isAuthorOfPublication6c5e2bd6-1ae0-41e8-a0f6-9b29d0c1b115
relation.isAuthorOfPublication36384aec-6adf-42ef-99ae-68f62b9a69b9
relation.isAuthorOfPublication.latestForDiscovery36384aec-6adf-42ef-99ae-68f62b9a69b9
sigepi.autor.atividadeYOSHIMURA, TANIA M.:10230:-1:S
sigepi.autor.atividadeKATO, ILKA T.:3089:-1:N
sigepi.autor.atividadeDEANA, ALESSANDRO M.:3423:-1:N
sigepi.autor.atividadeRIBEIRO, MARTHA S.:574:-1:N
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