Resveratrol radiomodifier effect on Danio rerio embriolarval assay
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2017
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
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The ionizing radiation can cause fatal damages to cells by the direct interaction with DNA and RNA or a series
of toxic reactions occasioning chemical and biological changes. There are compounds with radioprotective
potential, like resveratrol. For use the
organism. Resveratrol is a substance found in peanuts, grapes and wine and its production occurs in plants as a
response to physical, chemical and biological stress. Some studies
benefits. Danio rerio (zebrafish) is a vertebrate animal and has become the model of several studies related to
human diseases, due to its genomes similarity of 70 %, rapid embryonic development and the transparency o
the eggs, which make it possible to observe the effects during the test period. The aim of the present study
to verify the resveratrol radiomodifier effect on zebrafish during the embryolarval development by modified
Fish Embryo Acute Toxicity (FET)
(LC50) was 66.9 mg.L-1. Before, to understand the effects of radiation, was carried out the gamma radiation
lethal dose (LD50) assay and the LD50 was 25 Gy. With these results the projec
study of the radiomodifier effect of resveratrol in the presence of gamma radiation
Como referenciar
DAMASCENO, KELME C.; MAMEDE, FERNANDA C.S.; CAVALCANTE, ADRIANA K.; ROGERO, SIZUE O.; FERREIRA, MONICA L.; ROGERO, JOSE R. Resveratrol radiomodifier effect on Danio rerio embriolarval assay. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 22-27, 2017, Belo Horizonte, MG. Proceedings... Rio de Janeiro, RJ: Associação Brasileira de Energia Nuclear, 2017. Disponível em: http://repositorio.ipen.br/handle/123456789/28310. Acesso em: 04 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.