Fe, Zn, Se and Na increases in brains of individuals with cognitive decline
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Alzheimer's and Dementia
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Background: Although it has been known that trace elements play an
essential role in the human metabolism, the role of these elements in
neurological diseases still remains uncertain. Methods: Brain samples
from 22 normal and 28 demented individuals of both genders aged more
than 50 years from the Brain Bank of the Brazilian Ageing Brain Study
Group. The brain samples were cut using a titanium knife and then
freeze-dried. Neutron activation analysis was applied to assess Fe, Zn, Se,
Na, K, Rb concentrations. Certified reference materials, NIST 1566b Oyster Tissue and NIST 1577b Bovine Liver were analyzed for quality of the
analytical results. Cognitive evaluation was retrospectively gathered
through a semi-structured interview using the Clinical Dementia Scale
(CDR) and Informant Questionnaire on Cognitive Decline in the Elderly
(IQCODE). Participants were classified as cognitively normal if the CDR
was 0 and the IQCODE 3.20 and as demented if the CDR was 2 and
the IQCODE 3.80. Results: Comparisons between the results obtained for
the hippocampus of normal and demented individuals showed significantly
higher concentrations of Fe, Na, Se and Zn in the hippocampus of demented individual group (p0.05). On the other hand, the hippocampus of
the demented group presented lower K and Rb concentrations when compared to the hippocampus of the normal group. Conclusions: It is possible
that the disequilibrium found in this study could be related to cognitive
decline. However, further analysis with a larger group of both normal and
demented individuals, including intermediate rates of cognitive decline, is
needed.
Como referenciar
LEITE, RENATA E.P.; GRINBERG, LEA T.; FERRETTI, RENATA E.L.; FARFEL, JOSE M.; ROSEMBERG, SERGIO; PASQUALUCCI, CARLOS A.; SALDIVA, PAULO H.N.; NITRINI, RICARDO; JACOB FILHO, WILSON; SAIKI, MITIKO. Fe, Zn, Se and Na increases in brains of individuals with cognitive decline. Alzheimer's and Dementia, v. 4, p. T334, 2008. DOI: 10.1016/j.jalz.2008.05.976. Disponível em: http://repositorio.ipen.br/handle/123456789/25262. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.