In vitro and in vivo toxicity evaluation of resveratrol assisted gold nanoparticles

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dc.contributor.authorBARROS, JANAINA A.G.
dc.contributor.authorMAZIERO, JOANA S.
dc.contributor.authorMAMEDE, FERNANDA C.S.
dc.contributor.authorCAVALCANTE, ADRIANA K.
dc.contributor.authorROGERO, SIZUE O.
dc.contributor.authorBATISTA, JORGE G.S.
dc.contributor.authorVARCA, GUSTAVO H.C.
dc.contributor.authorROGERO, JOSE R.
dc.contributor.authorLUGAO, ADEMAR B.
dc.coverageNacionalpt_BR
dc.creator.eventoCONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGAOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 14.; EDICAO DO WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGAOS ARTIFICIAIS, 5.pt_BR
dc.date.accessioned2018-09-12T12:43:54Z
dc.date.available2018-09-12T12:43:54Z
dc.date.evento20-24 de agosto, 2017pt_BR
dc.description.abstractGold nanoparticles (AuNP) are being investigated for diagnostic and therapeutic nanomedicines considering their low toxicity and stability against oxidation, among other features. The increasing production and use of AuNP can result in release of them into aquatic environment and the impacts on the aquatic organisms are not clear and the safety of AuNPs are still under investigation. This work aimed analyze the toxicity of resveratrol assisted AuNP synthesized in buffer phosphate pH 7.0 with approximately 47 nm in DLS and 15 nm in TEM analysis and gold ionic solution (Au+3). Cytotoxicity by neutral red uptake method and acute ecotoxicological assay on Daphnia similis were used. AuNP presented no cytotoxicity up to 246 mg L-1 while Au+3 showed IC50=7.95 mg L-1. AuNP CE50 was 113.15 mg L-1 and for Au+3 0.05 mg L-1. More studies can be conducted for the determination of safety ionic Au+3 and AuNP concentrations in aquatic environment.pt_BR
dc.event.siglaSLABO; OBIpt_BR
dc.format.extent926-933pt_BR
dc.identifier.citationBARROS, JANAINA A.G.; MAZIERO, JOANA S.; MAMEDE, FERNANDA C.S.; CAVALCANTE, ADRIANA K.; ROGERO, SIZUE O.; BATISTA, JORGE G.S.; VARCA, GUSTAVO H.C.; ROGERO, JOSE R.; LUGAO, ADEMAR B. In vitro and in vivo toxicity evaluation of resveratrol assisted gold nanoparticles. In: CONGRESSO DA SOCIEDADE LATINO AMERICANA DE BIOMATERIAIS, ORGAOS ARTIFICIAIS E ENGENHARIA DE TECIDOS, 14.; EDICAO DO WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGAOS ARTIFICIAIS, 5., 20-24 de agosto, 2017, Maresias, SP. <b>Anais...</b> p. 926-933. Disponível em: http://repositorio.ipen.br/handle/123456789/29105.
dc.identifier.orcidhttps://orcid.org/0000-0002-2517-7772
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.orcidhttps://orcid.org/0000-0003-3396-6277
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29105
dc.local.eventoMaresias, SPpt_BR
dc.rightsopenAccesspt_BR
dc.subjectgold
dc.subjectnanoparticles
dc.subjectantioxidants
dc.subjectpolyphenols
dc.subjecttoxicity
dc.subjecttoxic materials
dc.titleIn vitro and in vivo toxicity evaluation of resveratrol assisted gold nanoparticlespt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorJOANA DA SILVA MAZIERO
ipen.autorJORGE GABRIEL DOS SANTOS BATISTA
ipen.autorJOSE ROBERTO ROGERO
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorGUSTAVO HENRIQUE COSTAVARCA
ipen.autorSIZUE OTA ROGERO
ipen.autorADRIANA KUCHINSKI CAVALCANTE
ipen.autorFERNANDA CAROLINE SILVA MAMEDE
ipen.autorJANAINA ALINE GALVÃO BARROS
ipen.codigoautor14163
ipen.codigoautor10274
ipen.codigoautor1118
ipen.codigoautor339
ipen.codigoautor8661
ipen.codigoautor1266
ipen.codigoautor12073
ipen.codigoautor14172
ipen.codigoautor14272
ipen.contributor.ipenauthorJOANA DA SILVA MAZIERO
ipen.contributor.ipenauthorJORGE GABRIEL DOS SANTOS BATISTA
ipen.contributor.ipenauthorJOSE ROBERTO ROGERO
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorGUSTAVO HENRIQUE COSTAVARCA
ipen.contributor.ipenauthorSIZUE OTA ROGERO
ipen.contributor.ipenauthorADRIANA KUCHINSKI CAVALCANTE
ipen.contributor.ipenauthorFERNANDA CAROLINE SILVA MAMEDE
ipen.contributor.ipenauthorJANAINA ALINE GALVÃO BARROS
ipen.date.recebimento18-09pt_BR
ipen.event.datapadronizada2017pt_BR
ipen.identifier.ipendoc24928pt_BR
ipen.notas.internasAnaispt_BR
ipen.type.genreArtigo
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relation.isAuthorOfPublication.latestForDiscovery0f2a10b8-41d0-414e-b836-16f7a849902b
sigepi.autor.atividadeBARROS, JANAINA A.G.:14272:740:Spt_BR
sigepi.autor.atividadeMAZIERO, JOANA S.:14163:740:Npt_BR
sigepi.autor.atividadeMAMEDE, FERNANDA C.S.:14172:740:Npt_BR
sigepi.autor.atividadeCAVALCANTE, ADRIANA K.:12073:740:Npt_BR
sigepi.autor.atividadeROGERO, SIZUE O.:1266:740:Npt_BR
sigepi.autor.atividadeBATISTA, JORGE G.S.:10274:740:Npt_BR
sigepi.autor.atividadeVARCA, GUSTAVO H.C.:8661:750:Npt_BR
sigepi.autor.atividadeROGERO, JOSE R.:1118:740:Npt_BR
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
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