Gold nanoparticles stabilized with gum arabic for cancer treatment

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dc.contributor.authorROSERO, WILMMER A.A.pt_BR
dc.contributor.authorNOGUEIRA, BEATRIZ R.pt_BR
dc.contributor.authorSOUZA, CARLA D. dept_BR
dc.contributor.authorGONZALEZ, ANDREZA A.D.C.C.pt_BR
dc.contributor.authorBARBEZAN, ANGELICA B.pt_BR
dc.contributor.authorZEITUNI, CARLOS A.pt_BR
dc.contributor.authorROSTELATO, MARIA E.C.M.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL NUCLEAR ATLANTIC CONFERENCEpt_BR
dc.date.accessioned2020-01-07T14:42:40Z
dc.date.available2020-01-07T14:42:40Z
dc.date.eventoOctober 21-25, 2019pt_BR
dc.description.abstractCancer is a group of diseases characterized by uncontrolled growth and abnormal spread of cells. The number of deaths due to cancer is higher than the ones caused by AIDS, tuberculosis and malaria combined. Among the different options of cancer treatment radiotherapy (teletherapy and brachytherapy) sta nds out. The presence of gold nanoparticles (AuNPs) may enhance energy deposition for teletherapy treatment. The use of nanoparticles for brachytherapy have been studied, and AuNPs is a good option once they can easily permeate tumor vasculature and remain in tumors. However, the tumor uptake of AuNPs may be significantly reduced due the attenuation with the formation of the protein coronas. The objective of this work is present the functionalization of AuNPs with arabic gum (GA). GA is a biocompatible, non toxic, water soluble, natural gum obtained from Acacia senegal tree. In this study, a synthesis of gold nanoparticles (AuNPs), based on Turkevich method, using citrate (NaCit) solution as reducing agent and a HAuCl4 solution, under vigorously stirring and boiling temperature, going from a light yellow to a wine red in three minutes. The functionalization of the nanoparticles was performed with Arabic gum solutions, in three different concentrations , which were a dded under stirring to the AuNPs already obtai ned. Samples were characterized to measure the size of the samples. Lower concentrations o GA in the solution presented smaller coated particles (up to 45 nm).pt_BR
dc.event.siglaINACpt_BR
dc.format.extent1946-1952pt_BR
dc.identifier.citationROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; SOUZA, CARLA D. de; GONZALEZ, ANDREZA A.D.C.C.; BARBEZAN, ANGELICA B.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M. Gold nanoparticles stabilized with gum arabic for cancer treatment. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 21-25, 2019, Santos, SP. <b>Proceedings...</b> Rio de Janeiro: Associação Brasileira de Energia Nuclear, 2019. p. 1946-1952. Disponível em: http://repositorio.ipen.br/handle/123456789/30592.
dc.identifier.orcid0000-0003-2943-6097pt_BR
dc.identifier.orcid0000-0002-7303-6720pt_BR
dc.identifier.orcid0000-0003-4609-2281pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2943-6097
dc.identifier.orcidhttps://orcid.org/0000-0002-7303-6720
dc.identifier.orcidhttp://orcid.org/0000-0003-1335-8864
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30592
dc.localRio de Janeiropt_BR
dc.local.eventoSantos, SPpt_BR
dc.publisherAssociação Brasileira de Energia Nuclear
dc.rightsopenAccesspt_BR
dc.subjectbrachytherapy
dc.subjectgold
dc.subjectgums
dc.subjectnanoparticles
dc.subjectneoplasms
dc.subjectradiotherapy
dc.subjecttherapy
dc.titleGold nanoparticles stabilized with gum arabic for cancer treatmentpt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorBEATRIZ RIBEIRO NOGUEIRA
ipen.autorANGELICA BUENO BARBEZAN
ipen.autorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.autorCARLOS ALBERTO ZEITUNI
ipen.autorANDREZA APARECIDA DEL CARMEN CASTRO GONZALEZ
ipen.autorCARLA DARUICH DE SOUZA
ipen.autorWILMMER ALEXANDER ARCOS ROSERO
ipen.codigoautor7563
ipen.codigoautor6417
ipen.codigoautor7
ipen.codigoautor944
ipen.codigoautor14495
ipen.codigoautor7717
ipen.codigoautor14860
ipen.contributor.ipenauthorBEATRIZ RIBEIRO NOGUEIRA
ipen.contributor.ipenauthorANGELICA BUENO BARBEZAN
ipen.contributor.ipenauthorMARIA ELISA CHUERY MARTINS ROSTELATO
ipen.contributor.ipenauthorCARLOS ALBERTO ZEITUNI
ipen.contributor.ipenauthorANDREZA APARECIDA DEL CARMEN CASTRO GONZALEZ
ipen.contributor.ipenauthorCARLA DARUICH DE SOUZA
ipen.contributor.ipenauthorWILMMER ALEXANDER ARCOS ROSERO
ipen.date.recebimento20-01
ipen.event.datapadronizada2019pt_BR
ipen.identifier.ipendoc26242pt_BR
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationbf595406-78bc-405b-afb9-a54dc01ee206
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relation.isAuthorOfPublicationda77b491-04ff-4c68-aa65-dead9208a48c
relation.isAuthorOfPublication02421b96-adef-4759-b25e-67d4759aa676
relation.isAuthorOfPublication525fa830-c87b-4bae-8423-2f254fde137f
relation.isAuthorOfPublication866434dc-2634-4567-8b4b-04e5ce06bf04
relation.isAuthorOfPublication05807c07-babd-4cb1-b3fa-79f812e50e90
relation.isAuthorOfPublication.latestForDiscovery05807c07-babd-4cb1-b3fa-79f812e50e90
sigepi.autor.atividadeROSTELATO, MARIA E.C.M.:7:230:Npt_BR
sigepi.autor.atividadeZEITUNI, CARLOS A.:944:230:Npt_BR
sigepi.autor.atividadeBARBEZAN, ANGELICA B.:6417:110:Npt_BR
sigepi.autor.atividadeGONZALEZ, ANDREZA A.D.C.C.:14495:230:Npt_BR
sigepi.autor.atividadeSOUZA, CARLA D. de:7717:230:Npt_BR
sigepi.autor.atividadeNOGUEIRA, BEATRIZ R.:7563:230:Npt_BR
sigepi.autor.atividadeROSERO, WILMMER A.A.:14860:230:Spt_BR
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