Synthesis and biological evaluation of boronated polyglycerol dendrimers as potential agent for neutron capture therapy
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2005
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; ENCONTRO NACIONAL DE APLICACOES NUCLEARES, 7th
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In this work, the polyglycerol dendrimer (PGLD) generation 5 was used to obtain a boronated macromolecule
for boron neutron capture therapy (BNCT). The PGLD dendrimer was synthesized by the ring opening
polymerization of deprotonated glycidol using polyglycerol as core functionality in a step-growth processes
denominated divergent synthesis. The PGLD dendritic structure was confirmed by gel permeation
chromatography (GPC), nuclear magnetic resonance (1
H-NMR, 13C-NMR) and matrix assisted laser
desorption/ionization (MALDI-TOF) techniques. The synthesized dendrimer presented low dispersion in
molecular weights (Mw/Mn = 1.05) and a degree of branching of 0.82, which characterize the polymer dendritic
structure. Quantitative neutron capture radiography (QNCR) was used to investigate the boron-10 enrichment of
the polyglycerol dendrimer. The in vitro citotoxicity to Chinese hamster ovary cells of 10B-PGLD dendrimer
indicate lower cytotoxicity, suggesting that the macromolecule is a biocompatible material.
Como referenciar
SILVA, G.S.; CAMILLO, M.A.P.; HIGA, O.Z.; PUGLIESI, R.; FERNANDES, E.G.R.; QUEIROZ, A.A.A. Synthesis and biological evaluation of boronated polyglycerol dendrimers as potential agent for neutron capture therapy. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; ENCONTRO NACIONAL DE APLICACOES NUCLEARES, 7th, ago. 28 - set. 2, 2005, Santos, SP. Anais... Disponível em: http://repositorio.ipen.br/handle/123456789/18237. Acesso em: 30 Dec 2025.
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