Evaluation of low-kV energy X-ray radiation effect on breast cancer cells incubated with gold nanoparticles capped with aminolevulinic acid, methyl aminolevulinate, and gamma-aminobutyric acid
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SSRN Electronic Journal
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Gold nanoparticles (AuNPs) have unique properties, including size-dependent optical and
electronic characteristics, biocompatibility, and ease of functionalization, making them
attractive for various diagnostic and therapeutic applications. The goal of this work was to verify
the potential application of gold nanoparticles capped with aminolevulinic acid (ALA), methyl
aminolevulinate (MALA), and gamma-aminobutyric acid (GABA) in low-energy X-ray diagnostics
and therapy of breast cancer. ALA and MALA induce the accumulation of protoporphyrin IX
(PpIX) in cancer cells. PpIX, in turn, can be excited by Cherenkov radiation, producing reactive
oxygen species after energy or electron transfer from the triplet excited state of PpIX to
molecular oxygen, which induces cell death by apoptosis or necrosis. The results indicated that
ALA and MALA nanoparticles promoted reduced cell viability by approximately 20% with X-ray
irradiation at an energy level of 35 kV for 5 minutes. Breast cancer cells possess GABA receptors,
allowing for targeted effects by GABANPs, which can enhance contrast and improve diagnostic
potential. GABAAuNPs also demonstrated decreased cell viability in ~10% following X-ray
irradiation, making them a promising material for both breast cancer diagnosis and treatment.
Como referenciar
LOPES, ISABELA S.; SANTOS, NOEMY R.; SILVA, GIOVANA D. da; VIEIRA, DANIEL P.; COURROL, LILIA C. Evaluation of low-kV energy X-ray radiation effect on breast cancer cells incubated with gold nanoparticles capped with aminolevulinic acid, methyl aminolevulinate, and gamma-aminobutyric acid. SSRN Electronic Journal, p. 1-14, 2023. DOI: 10.2139/ssrn.4600644. Disponível em: https://repositorio.ipen.br/handle/123456789/50077. Acesso em: 02 Jul 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.