Synthesis and characterization of hydrogels composed by different types of poly(vinyl alcohol)
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2010
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LATIN AMERICAN CONGRESS OF ARTIFICIAL ORGANS AND BIOMATERIALS, 6th
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PVA is a synthetic water-soluble, biodegradable and biocompatible polymer. It is widely used in
pharmaceutical and biomedical applications for controlled drug release. The basic properties of PVA are known
to depend upon the degree of polymerization and on the degree of hydrolysis as well. Thus, the aim of this study
was to develop a hydrogel with improved mechanical properties and also evaluate the influence of the different
PVAs in the hydrogels properties in order to assess their potential application in matrices for advanced
controlled drug release systems. The hydrogels were synthesized with agar, carrageen and PVAs holding
different hydrolysis (88 and 98 %) rates and molecular weight using gamma radiation from 60Co source in order
to promote an adequate crosslinking and sterilization simultaneously. The properties of the hydrogels formed
were determined by the analysis of the swelling ratio, gel content and mechanical properties. The results
indicated the matrices composed by partially hydrolyzed grade PVA presented enhanced mechanical properties
and crosslinking over the fully hydrolyzed grade. The properties of the PVA used for the preparation of the
evaluated hydrogels conferred different properties to the hydrogels and the molar mass played an important role
in the crosslinking process of fully hydrolyzed PVA grades.
Como referenciar
ALCANTARA, MARA T.S.; VARCA, GUSTAVO H.C.; AMARAL, RENATA H.; MATTOS, THAMIRES C.B.; RIELLA, HUMBERTO G.; LUGAO, ADEMAR B. Synthesis and characterization of hydrogels composed by different types of poly(vinyl alcohol). In: LATIN AMERICAN CONGRESS OF ARTIFICIAL ORGANS AND BIOMATERIALS, 6th, August 17-20, 2010, Gramado, RS. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/17976. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.