Silver and silver-iron nanoparticles synthesized by photoreduction for applications in cancer therapy
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2019
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SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE
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Metal nanoparticles have been extensively studied for various purposes including therapeutic applications for cancer. In this study, nanoparticles of silver and silver-iron with aminolevulinic acid (ALA) were synthesized using (ALA:AgNPs and ALA:AgFeNPs) the photoreduction method with a 300 W xenon lamp, characterized by UV/vis absorption, zeta potential, x-rays diffraction, FTIR and transmission electron microscopy. The sizes obtained were ~ 23 nm for silver and ~ 12 nm for iron. Cytotoxicity assays were performed on breast tumor cells (MCF-7) and prostate cancer cells (LNCaP). The results obtained showed that it was possible to synthesize silver and silver-iron nanoparticles by the photoreduction method, and to functionalize their surfaces with ALA, which was delivered to the cells and converted to protoporphyrin IX (PpIX).
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GONÇALVES, KARINA de O.; COURROL, LILIA C.; CORAZZA, FULVIO; VIEIRA, DANIEL P. Silver and silver-iron nanoparticles synthesized by photoreduction for applications in cancer therapy. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... DOI: 10.1109/SBFoton-IOPC.2019.8910264. Disponível em: http://repositorio.ipen.br/handle/123456789/30284. Acesso em: 30 Dec 2025.
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