Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy

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dc.contributor.authorLIMA, CASSIO A.
dc.contributor.authorGOULART, VIVIANE P.
dc.contributor.authorCASTRO, PEDRO A.A. de
dc.contributor.authorCORREA, LUCIANA
dc.contributor.authorBENETTI, CAROLINA
dc.contributor.authorZEZELL, DENISE M.
dc.contributor.editorKURACHI, CRISTINA
dc.contributor.editorSVANBERG, KATARINA
dc.contributor.editorTROMBERG, BRUCE J.
dc.contributor.editorBAGNATO, VANDERLEI S.
dc.coverageInternacionalpt_BR
dc.creator.eventoBIOPHOTONICS SOUTH AMERICApt_BR
dc.date.accessioned2015-07-21T14:14:39Z
dc.date.available2015-07-21T14:14:39Z
dc.date.eventoMay 23, 2015pt_BR
dc.description.abstractNonmelanoma skin cancers are the most common form of malignancy in humans. Between the traditional treatment ways, the photodynamic therapy (PDT) is a promising alternative which is minimally invasive and do not requires surgical intervention or exposure to ionizing radiation. The understanding of the cascade of effects playing role in PDT is not fully understood, so that define and understand the biochemical events caused by photodynamic effect will hopefully result in designing better PDT protocols. In this study we investigated the potential of the FTIR spectroscopy to assess the biochemical changes caused by photodynamic therapy after 10 and 20 days of treatment using 5-aminolevulinic acid (ALA) as precursor of the photosensitizer photoporphyrin IX (PpIX). The amplitude values of second derivative from vibrational modes obtained with FTIR spectroscopy showed similar behavior with the morphological features observed in histopathological analysis, which showed active lesions even 20 days after PDT. Thus, the technique has the potential to be used to complement the investigation of the main biochemical changes that photodynamic therapy promotes in tissue.
dc.event.siglaSPIEpt_BR
dc.format.extent95311J1-1 - 95311J1-7pt_BR
dc.identifier.citationLIMA, CASSIO A.; GOULART, VIVIANE P.; CASTRO, PEDRO A.A. de; CORREA, LUCIANA; BENETTI, CAROLINA; ZEZELL, DENISE M. Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy. In: KURACHI, CRISTINA (ed.); SVANBERG, KATARINA (ed.); TROMBERG, BRUCE J. (ed.); BAGNATO, VANDERLEI S. (ed.). In: BIOPHOTONICS SOUTH AMERICA, May 23, 2015, Rio de Janeiro, RJ. <b>Proceedings...</b> p. 95311J1-1 - 95311J1-7. (SPIE Proceedings Series, 9531). DOI: <a href="https://dx.doi.org/10.1117/12.2181067">10.1117/12.2181067</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/23813.
dc.identifier.doi10.1117/12.2181067
dc.identifier.orcidhttps://orcid.org/0000-0001-7404-9606
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/23813
dc.local.eventoRio de Janeiro, RJpt_BR
dc.publisherSociety of Photho-optical Instrumentation Engineerspt_BR
dc.relation.ispartofseriesSPIE Proceedings Series, 9531
dc.rightsopenAccesspt_BR
dc.subjectcarcinomas
dc.subjectskin diseases
dc.subjectfourier transform spectrometers
dc.subjectbiological radiation effects
dc.subjectaminolevulinic acid
dc.subjectphotosensitivity
dc.subjecttherapy
dc.titleBiochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopypt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorPEDRO ARTHUR AUGUSTO DE CASTRO
ipen.autorCAROLINA BENETTI
ipen.autorDENISE MARIA ZEZELL
ipen.autorLUCIANA CORRÊA
ipen.autorVIVIANE PEREIRA GOULART
ipen.codigoautor12053
ipen.codigoautor5866
ipen.codigoautor693
ipen.codigoautor10707
ipen.codigoautor6603
ipen.contributor.ipenauthorPEDRO ARTHUR AUGUSTO DE CASTRO
ipen.contributor.ipenauthorCAROLINA BENETTI
ipen.contributor.ipenauthorDENISE MARIA ZEZELL
ipen.contributor.ipenauthorLUCIANA CORRÊA
ipen.contributor.ipenauthorVIVIANE PEREIRA GOULART
ipen.date.recebimento15-07pt_BR
ipen.event.datapadronizada2015pt_BR
ipen.identifier.ipendoc20857pt_BR
ipen.identifier.ods3
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
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relation.isAuthorOfPublicatione9e0d5d6-99ac-40b5-a57c-5ec82d671ec9
relation.isAuthorOfPublication.latestForDiscoverye9e0d5d6-99ac-40b5-a57c-5ec82d671ec9
sigepi.autor.atividadeGOULART, VIVIANE P.:6603:-1:N
sigepi.autor.atividadeCASTRO, PEDRO A.A. DE:12053:930:N
sigepi.autor.atividadeCORREA, LUCIANA:10707:-1:N
sigepi.autor.atividadeBENETTI, CAROLINA:5866:920:N
sigepi.autor.atividadeZEZELL, DENISE M.:693:920:N
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