Radiotherapy compositional and mechanical effects evaluation in radicular dentin by FTIR spectroscopy and microhardness testing
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2019
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SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE
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Resumo
Head and neck cancers are responsible for 400 to
600 thousand of new cancer cases per year over the world,
presenting a mortality rate of 223 to 300 thousand per year.
Radiotherapy can be used as a definitive, adjuvant or palliative
treatment. One of the radiotherapy indirect side effect is the
radiation-related caries, characterized by presenting a painless,
rampant and rapid progression. Hard tissues can be affected by
the ionizing radiation, changing their composition, morphology
and mechanical properties, although there is a lack of studies
relating these changes with radiation caries. Thus, considering
that radicular dentin is a tissue with a high incidence of
radiation caries, this study aimed to evaluate the compositional
and mechanical changes of this tissue when submitted to
radiotherapy. To that, it was conducted an in vitro study with
45 bovine teeth roots, where 90 radicular dentin slabs of 4 x 4
cm were obtained. The samples were immersed in artificial
saliva and submitted to radiotherapy using cobalt-60,
simulating doses for head and neck cancers of 2 Gy per day per
6 weeks, accumulating a total of 60 Gy. FTIR spectroscopy and
microhardness testing were performed before and after the
radiotherapy. The spectra were analyzed in six IR fingerprint
bands: amide I, amide II, amide III, phosphate, carbonate ν2 and
carbonate ν3ν4. Statistical analysis was performed by Student’s
t-test and Wilcoxon test, considering the level of significance of
5%. The carbonate ν3ν4 and the amide III areas decreased after
the radiotherapy, presenting significant statistical difference
between both periods. These findings can be related to inorganic
and organic changes due to free radicals formation. The Knoop
microhardness value decreased after the radiotherapy, also
showing statistical difference, which can be associated to
collagen reorganization or denaturation and to inorganic
changes, leading the tissue to be more prone to cracks
formation. It can be concluded that the radiotherapy affects the
compositional and mechanical properties of the radicular
dentin, and this fact should be considered in future studies.
Como referenciar
FIGUEREDO, DANIELA C.; DEL VALLE, MATHEUS; ZEZELL, DENISE M.; DAGUANO, JULIANA K.M.B.; ANA, PATRICIA A. Radiotherapy compositional and mechanical effects evaluation in radicular dentin by FTIR spectroscopy and microhardness testing. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... DOI: 10.1109/SBFoton-IOPC.2019.8910209. Disponível em: http://repositorio.ipen.br/handle/123456789/30285. Acesso em: 30 Dec 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.