Effectiveness of the hydrogel dressing crosslinked and sterilized by gamma radiation
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2019
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE
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Resumo
Chronic wounds of difficult cicatrization are more incidents with an increased in life expectancy. The hydrogel
with silver nanoparticles developed at the Nuclear Energetic Research Institute, crosslinked and sterilized by
Gamma radiation, is inexpensive and has a simple manufacturing process that seems to be an alternative to the
treatment of injuries. This experimental study compared the healing process of second intention of skin wounds
of 4cm² on the back of 69 Wistar rats, considering the effectiveness of hydrogel dressings with silver
nanoparticles. The animals were distributed in three groups that received treatment with hydrogel dressing,
hydrogel with 22ppm of silver nanoparticles and hydrogel with 44ppm of silver nanoparticles, and the dressings
were performed every 48 hours. The project was approved by the Animal Experiments Committee. Hydrogel
dressings are transparent and allow accurate visualization of the center of the lesion. The part of the dressing in
contact with the wound kept the medium moist, promoting interaction with the fluid of the lesion, besides
adsorbing the moisture produced. The dressing replacement didn’t cause discomfort or pain, since the animals
were manually contained during the procedure, and the cover is easy to remove without causing trauma to the
healing tissue. Wounds remained free of fibrin formation and necrosis, and serous exudation of lesions was scarce.
At 21 days all the lesions were healed showing that dressings weren’t negative to the second intention healing
process.
Como referenciar
GEMELLI, KARINE K.; SOUSA, GRAZIELLY M. de; GEMELLI, TIAGO F.; FERREIRA, OBEDE R.; OLIVEIRA, MARIA J.A. de; ALCANTARA, MARA T.S.; LUGAO, ADEMAR B. Effectiveness of the hydrogel dressing crosslinked and sterilized by gamma radiation. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 21-25, 2019, Santos, SP. Proceedings... Rio de Janeiro: Associação Brasileira de Energia Nuclear, 2019. p. 1879-1885. Disponível em: http://repositorio.ipen.br/handle/123456789/30591. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.