Elevated iron and zinc in alzheimer hippocampus
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Alzheimer's and Dementia
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Background: Iron and zinc are essential for the normal brain physiology.
However an imbalance of these metals has been postulated to play a role in
the pathogenesis of AD. We aimed to correlate levels of iron and zinc with
the cognitive status and beta amyloid burden in postmortem well-characterized
cases. Methods: Subjects with AD (n ¼ 13) and normal cognition (n ¼ 19) of
the Brain Brain of Brazilian Aging Brain Study Group were classified according to the clinical and neuropathological evaluations. The clinical diagnosis
was established through a postmortem interview with an informant including
validated scales and questionnaries The neuropathological examinations were
carried out based on accepted criteria, using immunohistochemistry. Neuropathologically, AD was defined by a CERAD 3 B and a Braak and Braak 3 IV.
Levels of Fe and Zn were measured in the hippocampus using instrumental
neutron activation analysis (INAA). Certified reference materials were analysed for assuring the quality of the analitycal results. Protocols were approved
by the local ethics committee. The statistical analysis was performed using the
IBM PAWS Statistics Package v.18 and Minitab Statistical Software v.15.
Results: Significantly higher (p < 0.05) concentrations for Fe and Zn were
found in the hippocampus of AD cases. The level of these elements was correlated to the amyloid plaques burden. Conclusions: Brain iron and zinc accumulation are a prominent feature of advanced Alzheimer disease. Recent
evidence suggests that beta amyloid precipitation and toxicity by formation
of H2O2 and increase of oxidative stress in AD are caused by abnormal interactions with metal ions, especially Zn and Fe. Our findings corroborate this
hypothesis. However the exactly role of the iron and zinc alterations in brain
in the pathogenesis of AD is yet to be clarifyed.
Como referenciar
LEITE, RENATA E.; GRINBERG, LEA T.; FERRETTI, RENATA E.L.; FARFEL, JOSE M.; ALHO, ANA T.D.L.; ANDRADE, MARA P.; POLICHISO, LIVIA; TAMPELLINI, EDILAINE; LIMA, MARIA C.; CAETANO JUNIOR, ANTONIO; OLIVEIRA, KATIA C.; PASQUALUCCI, CARLOS A.; NITRINI, RICARDO; JACOB FILHO, WILSON; SAIKI, MITIKO. Elevated iron and zinc in alzheimer hippocampus: a postmortem study using neutron activation analysis. Alzheimer's and Dementia, v. 6, n. 4S_Part_8, p. S236, 2010. DOI: 10.1016/j.jalz.2010.05.765. Disponível em: http://repositorio.ipen.br/handle/123456789/25264. Acesso em: 20 Mar 2026.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.