Brazil radioactive sources production for cancer treatment
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2016
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Medical Physics International
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The modality, known as brachytherapy, was performed in Brazil by only a hand full of hospitals at an
extremely high cost. For producing new sources, five major areas must be considered: 1) source production:
nuclear activation and/or radiochemical reaction; 2) welding; 3) Quality control: leakage tests; 4) Dosimetry
and metrology; 5) Operational procedures; 6) validation studies. To perform all steps, a multidisciplinary team
works together to overcome difficulties. - Iridium-192 pellets: In Brazil there are 140 machines with pellets
that replacement every 5 years. Our new production line has assembly, welding and quality control hot cells. -
Iridium-192 wires: Produced since 1999. The wire is activated at IPENs IEA-R1 reactor for 30 hours with
5x1013 n/cm-2.s-1 neutron flux resulting in 192 mCi maximum activity. - Iridium-192 seed: New seed for
ophthalmic cancer treatment. The irradiation device presented 90% activity homogeneity. We are still testing
in-vivo. - Iodine-125 seeds: Largely used in low dose brachytherapy. I-125 binding yield achieved with our
new reaction was 80%; Laser welding presented 70% efficiency. Approved in all leakage tests. - Other
ongoing projects: Veterinary brachytherapy, Waste management, Radionecrosis healing with laser, calibrations
sources production, linear accelerator calculations for hospitals, sources with polymeric matrix Our Iodine-125
seeds will be available in 2018. All other projects are advancing. We will continue to develop new products
hoping to help the Brazilian population fight against cancer. For producing new sources, five major areas must
be considered: 1) source production: nuclear activation and/or radiochemical reaction; 2) welding;
3) Quality control:eakage tests; 4) Dosimetry and metrology; 5) Operational procedures;
6) validation studies. To perform all steps, a multidisciplinary team works together to overcome difficulties
Como referenciar
ROSTELATO, MARIA E.; SOUZA, CARLA D.; ZEITUNI, CARLOS A.; MOURA, JOAO A.; MARQUES, JOSE R.O.; COSTA, OSVALDO L.; FEHER, ANSELMO; RODRIGUES, BRUNA T.; SOUZA, DAIANE C.B. de; PELEIAS JUNIOR, FERNANDO S.; SORGATTI, ANDERSON; MOSCA, RODRIGO; MOURA, EDUARDO S. de; ABREU, RODRIGO T.; SOUZA, RAQUEL V. DE; NOGUEIRA, BEATRIZ R. Brazil radioactive sources production for cancer treatment. Medical Physics International, v. 4, n. 2, p. 237-237, 2016. Disponível em: http://repositorio.ipen.br/handle/123456789/28170. Acesso em: 13 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.