Application of INAA in the study of metallic ions related to toxicity
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2007
Autores IPEN
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th
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Resumo
The 316L stainless steel which is commonly used as biomaterial in metallic implants has shown toxic effect in
cytotoxicity in vitro assay by neutral red uptake methodology. Instrumental neutron activation analysis was
applied to evaluate metal composition in the steel and in the extract composed by cell culture medium (MEM)
where the sample remained immersed during 10 days at 37 o
C. The aim of this study was to determine the level
and identify the elements related to cytotoxicity, in solutions containing metallic ions with different associations
and concentrations. The results showed Co, Cr and Ni elements in the extract which are metallic elements
previously associated to toxicity. The association of Cr and Ni resulted in toxicity although these elements when
individually present in the medium did not show any toxicity effect. On the other hand, the association of Co to
Cr + Ni reduced the cytotoxic effect.
Como referenciar
ROGERO, SIZUE O.; AMARAL, RENATA H.; COSTA, ISOLDA; SAIKI, MITIKO. Application of INAA in the study of metallic ions related to toxicity. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th, Sept. 30 - Oct. 5, 2007, Santos, SP. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/11822. Acesso em: 20 Mar 2026.
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