Toxicity study using rat (WISTAR) model of a hydrogel dressing with silver nanoparticles crosslinked and sterilized by gamma radiation

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dc.contributor.authorSOUSA, GRAZIELLY M. dept_BR
dc.contributor.authorGEMELLI, KARINE K.pt_BR
dc.contributor.authorMARTINS, OZENILDE A.R.pt_BR
dc.contributor.authorOLIVEIRA, MARIA J.A. dept_BR
dc.contributor.authorALCANTARA, MARA T.S.pt_BR
dc.contributor.authorLUGAO, ADEMAR B.pt_BR
dc.contributor.authorROGERO, JOSE R.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL NUCLEAR ATLANTIC CONFERENCEpt_BR
dc.date.accessioned2020-01-07T14:23:44Z
dc.date.available2020-01-07T14:23:44Z
dc.date.eventoOctober 21-25, 2019pt_BR
dc.description.abstractSilver nanoparticles (NPAg) have a bactericidal and bacteriostatic action in combination with hydrogels to recover the damaged tissue, promoting healing of the wound. The objective of this study was to evaluate the toxicity of the hydrogel dressing with NPAg from the analysis of possible toxic effects on renal and hepatic functions. It is an experimental study with 85 male Wistar rats, young adults. Nanoprate hydrogel and bidrogel dressings were used at concentrations of 22 and 44 ppm, both crosslinked and sterilized by irradiation with gamma rays at the 25 kGy dose at the center of radiation technology (CTR). The animals were distributed according to the treatment received after surgical induction of the wound on the animal's back. They were euthanized with 24 hours, 3, 7, 14, 21 and 30 days and after collecting the blood to determine the biochemical parameters. The project was approved by CEUA FAPAC ITPAC PORTO. Data were analyzed using the Past, Shapiro-Wilk and Kruskal-Wallis programs. For distribution and comparison data ANOVA and Tukey test with a significance level of 95%. No changes were observed in relation to biochemical parameters (TGP, TGO, urea and creatinine), and there were no statistically significant differences between the three groups of animals, independent of time. It was possible to observe that the animals treated with 44 ppm had always lower mean values than the other two groups in all analyzes. The study showed that the dressings of NPAg tested may not induce toxicity, being necessary to complement with other tests, such as histopathological study and atomic absorption spectroscopy.pt_BR
dc.event.siglaINACpt_BR
dc.format.extent1871-1878pt_BR
dc.identifier.citationSOUSA, GRAZIELLY M. de; GEMELLI, KARINE K.; MARTINS, OZENILDE A.R.; OLIVEIRA, MARIA J.A. de; ALCANTARA, MARA T.S.; LUGAO, ADEMAR B.; ROGERO, JOSE R. Toxicity study using rat (WISTAR) model of a hydrogel dressing with silver nanoparticles crosslinked and sterilized by gamma radiation. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE, October 21-25, 2019, Santos, SP. <b>Proceedings...</b> Rio de Janeiro: Associação Brasileira de Energia Nuclear, 2019. p. 1871-1878. Disponível em: http://repositorio.ipen.br/handle/123456789/30590.
dc.identifier.orcid0000-0002-2517-7772pt_BR
dc.identifier.orcid0000-0002-1737-3191pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2517-7772
dc.identifier.orcidhttps://orcid.org/0000-0002-1737-3191
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/30590
dc.localRio de Janeiropt_BR
dc.local.eventoSantos, SPpt_BR
dc.publisherAssociação Brasileira de Energia Nuclear
dc.rightsopenAccesspt_BR
dc.subjectabsorption spectroscopy
dc.subjectgamma radiation
dc.subjecthealing
dc.subjecthydrogels
dc.subjectmice
dc.subjectnanoparticles
dc.subjectsilver
dc.subjectsterilization
dc.subjecttoxicity
dc.subjectwounds
dc.titleToxicity study using rat (WISTAR) model of a hydrogel dressing with silver nanoparticles crosslinked and sterilized by gamma radiationpt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorKARINE KUMMER GEMELLI
ipen.autorJOSE ROBERTO ROGERO
ipen.autorADEMAR BENEVOLO LUGAO
ipen.autorMARA TANIA S. ALCANTARA
ipen.autorMARIA JOSE ALVES DE OLIVEIRA
ipen.autorGRAZIELLY MENDES DE SOUSA
ipen.codigoautor14698
ipen.codigoautor1118
ipen.codigoautor339
ipen.codigoautor3820
ipen.codigoautor3310
ipen.codigoautor14796
ipen.contributor.ipenauthorKARINE KUMMER GEMELLI
ipen.contributor.ipenauthorJOSE ROBERTO ROGERO
ipen.contributor.ipenauthorADEMAR BENEVOLO LUGAO
ipen.contributor.ipenauthorMARA TANIA S. ALCANTARA
ipen.contributor.ipenauthorMARIA JOSE ALVES DE OLIVEIRA
ipen.contributor.ipenauthorGRAZIELLY MENDES DE SOUSA
ipen.date.recebimento20-01
ipen.event.datapadronizada2019pt_BR
ipen.identifier.ipendoc26240pt_BR
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
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sigepi.autor.atividadeROGERO, JOSE R.:1118:-1:Npt_BR
sigepi.autor.atividadeLUGAO, ADEMAR B.:339:740:Npt_BR
sigepi.autor.atividadeALCANTARA, MARA T.S.:3820:-1:Npt_BR
sigepi.autor.atividadeOLIVEIRA, MARIA J.A. de:3310:750:Npt_BR
sigepi.autor.atividadeGEMELLI, KARINE K.:14698:750:Npt_BR
sigepi.autor.atividadeSOUSA, GRAZIELLY M. de:14796:-1:Spt_BR
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