Plasma clearance of chylomicron remnants is delayed in aged subjects

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dc.contributor.authorTAVONI, T.M.pt_BR
dc.contributor.authorVINAGRE, C.G.pt_BR
dc.contributor.authorFREITAS, F.R.pt_BR
dc.contributor.authorMESQUITA, C.H.pt_BR
dc.contributor.authorVINAGRE, J.C.pt_BR
dc.contributor.authorMARIANI, A.C.pt_BR
dc.contributor.authorKALIL-FILHO, R.pt_BR
dc.contributor.authorMARANHAO, R.C.pt_BR
dc.coverageInternacionalpt_BR
dc.date.accessioned2019-07-25T12:05:04Z
dc.date.available2019-07-25T12:05:04Z
dc.date.issued2018pt_BR
dc.description.abstractAim: Dietary fats absorbed in the intestine are transported in the circulation as chylomicrons and remnants that have atherogenic potential. Although postprandial lipidemia is increased in older subjects, the specific chylomicron metabolism has not been explored in older subjects nor compared to young subjects, which is the focus of this study. Methods: After a 12 h fast, artificially-made emulsions similar to lymph chylomicrons and doubly labeled with radioactive cholesteryl esters and triglycerides were intravenously injected in 23 older (66±4 years) and 20 young (24±3 years) subjects. Sequential blood samples were collected to determine fractional clearance rates (FCR, in min-1) by compartmental analysis. Results: Older subjects had higher LDL-cholesterol (p<0.001) and triglycerides (p<0.0001) than young subjects; HDL-cholesterol presented no difference. The emulsion cholesteryl-ester FCR was lower in older subjects compared to the young (p¼0.0001). The emulsion triglyceride FCR did not differ in the two groups. Tested in vitro, however, the lipolysis of the emulsion triglycerides was less intense in the older than in the young subjects. Conclusions: As delayed removal of remnants, indicated by the pronouncedly smaller cholesteryl ester FCR, is related to the presence of cardiovascular diseases, this can be a risk factor which could accelerate atherogenic complications occurring in aged subjects.pt_BR
dc.format.extente157-e157pt_BR
dc.identifier.citationTAVONI, T.M.; VINAGRE, C.G.; FREITAS, F.R.; MESQUITA, C.H.; VINAGRE, J.C.; MARIANI, A.C.; KALIL-FILHO, R.; MARANHAO, R.C. Plasma clearance of chylomicron remnants is delayed in aged subjects: a study with artificial emulsions. <b>Atherosclerosis</b>, v. 275, p. e157-e157, 2018. DOI: <a href="https://dx.doi.org/10.1016/j.atherosclerosis.2018.06.468">10.1016/j.atherosclerosis.2018.06.468</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/29949.
dc.identifier.doi10.1016/j.atherosclerosis.2018.06.468pt_BR
dc.identifier.issn0021-9150pt_BR
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/29949
dc.identifier.vol275pt_BR
dc.relation.ispartofAtherosclerosispt_BR
dc.rightsopenAccesspt_BR
dc.subjectlipids
dc.subjectchylomicrons
dc.subjectblood plasma
dc.subjectclearance
dc.subjectblood plasma
dc.subjectcardiovascular diseases
dc.titlePlasma clearance of chylomicron remnants is delayed in aged subjectspt_BR
dc.typeResumos em periódicospt_BR
dspace.entity.typePublication
ipen.autorCARLOS HENRIQUE DE MESQUITA
ipen.codigoautor1149
ipen.contributor.ipenauthorCARLOS HENRIQUE DE MESQUITA
ipen.date.recebimento19-07
ipen.identifier.fi4.255pt_BR
ipen.identifier.ipendoc25732pt_BR
ipen.identifier.iwosWoSpt_BR
ipen.range.fi3.000 - 4.499
ipen.subtituloa study with artificial emulsionspt_BR
ipen.type.genreResumo
relation.isAuthorOfPublication20d22e5e-a0d1-4286-b4d9-20e5ac53cb51
relation.isAuthorOfPublication.latestForDiscovery20d22e5e-a0d1-4286-b4d9-20e5ac53cb51
sigepi.autor.atividadeMESQUITA, C.H.:1149:240:Npt_BR
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