In vitro in vivo studies in Balb-c and nude mice of a new sup(177)Lu-bombesin analog developed for prostate tumor diagnosis and treatment

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dc.contributor.authorPUJATTI, PRISCILLA B.pt_BR
dc.contributor.authorSANTOS, JOSEFINA S.pt_BR
dc.contributor.authorCOUTO, RENATA M.pt_BR
dc.contributor.authorSUZUKI, MIRIAM F.pt_BR
dc.contributor.authorMENGATTI, JAIRpt_BR
dc.contributor.authorARAUJO, ELAINE B. dept_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1stpt_BR
dc.date.accessioned2014-11-17T17:16:39Zpt_BR
dc.date.accessioned2014-11-18T17:19:48Zpt_BR
dc.date.accessioned2015-04-01T23:16:25Z
dc.date.available2014-11-17T17:16:39Zpt_BR
dc.date.available2014-11-18T17:19:48Zpt_BR
dc.date.available2015-04-01T23:16:25Z
dc.date.eventoSeptember 27 - October 2, 2009pt_BR
dc.description.abstractIn this work we describe the radiolabeling with 177Lu and some properties of the novel bombesin analog BBNp6 – DOTA-X-BBN(6-14), where X is a spacer of six aminoacids. Bombesin (BBN) is an analog of human gastrin releasing peptide (GRP) isolated from the skin of the frog Bombina bombina in 1970. Development of radiolabeled BBN derivatives as agents for diagnostic imaging and systemic radiotherapy has increased considerable because of the observation that GRP receptors (GRPr) are over-expressed in a variety of human tumor cells, such as prostate tumor cells. 177Lu-labeled peptides are attractive due to the excellent radiophysical properties and commercial availability of the radiometal. BBNp6 was labeled with high yield after reacting with 92.5 MBq of 177LuCl3 at 90 °C for 30 minutes and this mixture kept stable for more than 96 hours at 4 ºC and 1 hour in human plasma. In vivo studies showed a multicompartimental distribution model with fast blood clearance, mainly performed by renal pathway. In addition, 177Lu-BBNp6 showed high affinity for PC-3 tumor xenografts, but not for pancreas and intestine (GRP positive tissues), suggesting its specificity and usefulness for prostate tumor treatment. Moreover, scintigraphic images showed that this derivative can also be a tool in this tumor diagnosis. So, BBNp6 is a promising radiopharmaceutical for prostate tumor imaging and treatment.
dc.event.siglaINAC; ENAN; ENFIR; ENINpt_BR
dc.identifier.citationPUJATTI, PRISCILLA B.; SANTOS, JOSEFINA S.; COUTO, RENATA M.; SUZUKI, MIRIAM F.; MENGATTI, JAIR; ARAUJO, ELAINE B. de. In vitro in vivo studies in Balb-c and nude mice of a new sup(177)Lu-bombesin analog developed for prostate tumor diagnosis and treatment. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. <b>Proceedings...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/13219.
dc.identifier.orcidhttps://orcid.org/0000-0003-0456-5589
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/13219pt_BR
dc.local.eventoRio de Janeiro, RJpt_BR
dc.publisherSao Paulo: ABEN, 2009pt_BR
dc.rightsopenAccesspt_BR
dc.subjectevaluationpt_BR
dc.subjectfailurespt_BR
dc.subjectfuzzy logicpt_BR
dc.subjecthuman factorspt_BR
dc.subjectiear-1 reactorpt_BR
dc.subjectnumerical datapt_BR
dc.subjectprobabilistic estimationpt_BR
dc.subjectprobabilitypt_BR
dc.subjectreactor corespt_BR
dc.subjectreactor operatorspt_BR
dc.subjectreactor safetypt_BR
dc.subjectreliabilitypt_BR
dc.subjectrisk assessmentpt_BR
dc.titleIn vitro in vivo studies in Balb-c and nude mice of a new sup(177)Lu-bombesin analog developed for prostate tumor diagnosis and treatmentpt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorJAIR MENGATTI
ipen.autorELAINE BORTOLETI DE ARAUJO
ipen.autorMIRIAM FUSSAE SUZUKI
ipen.autorRENATA MARTINUSSI COUTO
ipen.autorJOSEFINA DA SILVA SANTOS
ipen.autorPRISCILLA BRUNELLI PUJATTI
ipen.codigoautor1498
ipen.codigoautor664
ipen.codigoautor557
ipen.codigoautor3441
ipen.codigoautor2516
ipen.codigoautor6795
ipen.contributor.ipenauthorJAIR MENGATTI
ipen.contributor.ipenauthorELAINE BORTOLETI DE ARAUJO
ipen.contributor.ipenauthorMIRIAM FUSSAE SUZUKI
ipen.contributor.ipenauthorRENATA MARTINUSSI COUTO
ipen.contributor.ipenauthorJOSEFINA DA SILVA SANTOS
ipen.contributor.ipenauthorPRISCILLA BRUNELLI PUJATTI
ipen.date.recebimento10-05pt_BR
ipen.event.datapadronizada2009pt_BR
ipen.identifier.ipendoc15332pt_BR
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
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sigepi.autor.atividadePUJATTI, PRISCILLA B.:6795:110:Spt_BR
sigepi.autor.atividadeSANTOS, JOSEFINA S.:2516:110:Npt_BR
sigepi.autor.atividadeCOUTO, RENATA M.:3441:110:Npt_BR
sigepi.autor.atividadeSUZUKI, MIRIAM F.:557:810:Npt_BR
sigepi.autor.atividadeMENGATTI, JAIR:1498:110:Npt_BR
sigepi.autor.atividadeARAUJO, ELAINE B. de:664:110:Npt_BR
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