Effects of binding metronidazole to a copper acetate compound on radiosensitizer properties

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dc.contributor.authorNEGRON, ANA C.V.pt_BR
dc.contributor.authorROGERO, SIZUEpt_BR
dc.contributor.authorCRUZ, AUREA S.pt_BR
dc.contributor.authorSILVA, DENISE O.pt_BR
dc.coverageInternacionalpt_BR
dc.creator.eventoINTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1stpt_BR
dc.date.accessioned2014-11-17T18:19:38Zpt_BR
dc.date.accessioned2014-11-18T18:26:30Zpt_BR
dc.date.accessioned2015-04-02T05:01:01Z
dc.date.available2014-11-17T18:19:38Zpt_BR
dc.date.available2014-11-18T18:26:30Zpt_BR
dc.date.available2015-04-02T05:01:01Z
dc.date.eventoSeptember 27 - October 2, 2009pt_BR
dc.description.abstractCopper compounds exhibit interesting biological properties. Nitroimidazoles show radiosensitizer properties for radiotherapy tumor treatment. In the present work, the effect of binding metronidazole (1-(2-hidroxyethyl)-2- methyl-5-nitroimidazole = MTZ) to copper-acetate on the radiosensitizer properties has been investigated. A compound of copper-acetate-MTZ was prepared and characterized. The experiments were carried out by gamma-irradiation of Hep2 (human larynx cancer) cells under hypoxic conditions. The radiation doses for 50% cell survival in the presence of radiosensitizer were about 8.2 Gy for CuAcMTZ or free MTZ. The effect of binding metronidazole to copper acetate on radiosensitizer properties is mainly related to the radiosensitizer process which involves two events for CuAcMTZ in contrast to one event observed for the MTZ free drug.
dc.event.siglaINAC; ENAN; ENFIR; ENINpt_BR
dc.identifier.citationNEGRON, ANA C.V.; ROGERO, SIZUE; CRUZ, AUREA S.; SILVA, DENISE O. Effects of binding metronidazole to a copper acetate compound on radiosensitizer properties. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 9th; MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 16th; MEETING ON NUCLEAR INDUSTRY, 1st, September 27 - October 2, 2009, Rio de Janeiro, RJ. <b>Proceedings...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/16582.
dc.identifier.orcidhttps://orcid.org/0000-0003-3396-6277
dc.identifier.urihttp://repositorio.ipen.br/handle/123456789/16582pt_BR
dc.local.eventoRio de Janeiro, RJpt_BR
dc.publisherSao Paulo: ABEN, 2009pt_BR
dc.rightsopenAccesspt_BR
dc.subjectcell culturespt_BR
dc.subjectcobalt 60pt_BR
dc.subjectcopper compoundspt_BR
dc.subjectcopperpt_BR
dc.subjectculture mediapt_BR
dc.subjectexperimental datapt_BR
dc.subjectgamma radiationpt_BR
dc.subjectlarynxpt_BR
dc.subjectmetronidazolept_BR
dc.subjectradiation dosespt_BR
dc.subjectradioprotective substancespt_BR
dc.subjectradiosensitivity effectspt_BR
dc.subjecttumor cellspt_BR
dc.titleEffects of binding metronidazole to a copper acetate compound on radiosensitizer propertiespt_BR
dc.typeTexto completo de eventopt_BR
dspace.entity.typePublication
ipen.autorSIZUE OTA ROGERO
ipen.codigoautor1266
ipen.contributor.ipenauthorSIZUE OTA ROGERO
ipen.date.recebimento09-10pt_BR
ipen.event.datapadronizada2009pt_BR
ipen.identifier.ipendoc15167pt_BR
ipen.notas.internasProceedingspt_BR
ipen.type.genreArtigo
relation.isAuthorOfPublicationadecaf83-1d61-4fa2-b7e6-4cf91494610d
relation.isAuthorOfPublication.latestForDiscoveryadecaf83-1d61-4fa2-b7e6-4cf91494610d
sigepi.autor.atividadeROGERO, SIZUE:1266:-1:Npt_BR

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