Synthesis and characterization of phosphate glass microspheres for radiotherapy applications
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2007
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INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th
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Glass microspheres containing radioisotopes 90Y or 32P can be used for cancer
radiotherapy. 90Y and 32P emit β
-
particles with short penetration range of about 2.5 mm in
living tissue with the half-life of respectively 2.7 days and 14.3 days. Glass microspheres
containing such radioisotopes with suitable activity can be easily introduced in specific
human organs as liver, stomach, pancreas, and uterus to kill cancer cells, reducing
significantly damages to other health tissues allowing a major therapeutic effect. The use of
Y2O3-Al2O3-SiO2 glass microspheres for cancer therapy is an efficient alternative compared to
conventional chemotherapy treatments. However, the activity of the glass microspheres with
90Y is relatively low, due to the limitation of content of Y2O3 to only 17 mol %, and short
half-life, in a way that 90Y may decay substantially even before the treatment. A potential
alternative is to produce microspheres with high content of 31P that could be transmuted to 32P
with higher activity and longer half-life than 90Y. In the present work phosphate glass
microspheres were produced with different compositions and particle size distribution in the
range of 20 µm to 30 µm by using two different thermal processes to spherodize glass
particles originally with irregular shapes. Samples were characterized by Differential Thermal
Analysis, X-rays diffraction, and Energy Dispersive X-rays Fluorescence Spectroscopy. The
glass dissolution rate in water was determined at 90
oC, and in Simulated Body Fluid (SBF) at
37oC. Glasses with dissolution rates close to 10-5 g/(cm2
.d) were obtained, which make them
suitable for the present application. Scanning Electron Microscopy was used to evaluate the
shape of the microspheres before and after the dissolution tests. The cytotoxicity tests showed
that these microspheres can be used for biological applications.
Como referenciar
SENE, FRANK F.; MARTINELLI, JOSE R.; OKUNO, EMICO. Synthesis and characterization of phosphate glass microspheres for radiotherapy applications. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; MEETING ON NUCLEAR APPLICATIONS, 8th/ MEETING ON REACTOR PHYSICS AND THERMAL HYDRAULICS, 15th, Sept. 30 - Oct. 5, 2007, Santos, SP. Proceedings... Disponível em: http://repositorio.ipen.br/handle/123456789/18096. Acesso em: 30 Dec 2025.
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