Study of a new formulation for a phosphorus-32 polymeric source for use in brachytherapy
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2024
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Medical Physics
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Purpose: To evaluate a new material for a phosphorus-32 polymeric film to use in brachytherapy for paraspinal and
intracranial tumors and to analyze its activity distribution. Methods: As phosphorus-32 comes in the form of
orthophosphoric acid, several tests were conducted to determine the best resin to encapsulate it. Initially, acid without
radiation was used. Each test was repeated at least five times to ensure its result. Two variables were checked to
evaluate the results: whether the resin cured or not, and if the final product was flexible. All tests were conducted with
the selected resin being poured in molds of 5.0 x 5.0 x 0.04 cm. After selecting the considered suitable resins, acid with
the active phosphorus-32 was used to produce the source. The film’s activity was measured on an ionization chamber
detector. After measuring the activity from the whole film, it was cut into pieces of 1.0 x 1.0 cm and then measured again
to verify the activity’s distribution. Results: From the resin tests, two of them stood out, for both their curing properties
and malleability: silicone rubber with platinum catalyst and polyvinyl alcohol (PVA). Other resins evaluated whether did
not cure or the film was considered not flexible. The activity measurements for the silicone rubber samples had a mean
value of 227.92 ± 1.30 MBq (or 6.160 ± 0.005 mCi) and the distribution was acceptable. For the PVA, the activity mean
value was 243.09 ± 1.39 MBq (or 6,573 ± 0.005 mCi) and the distribution was also acceptable. Conclusion: This work
indicates a potential for a new flexible brachytherapy source, which could improve the surgical technique for central
nervous system tumor resection and treatment. The activity results were promising according to the literature for a HDR
source and further investigation on its dosimetry is needed to evaluate it.
Como referenciar
TEODORO, L.E.H.; TALACIMON, C.F.; SILVA, A.C.K.D.S.; BURIN, A.L.; MEDEIROS, I.M.M.A.; RIGO, M.E.Z.; RODRIGUES, P.S.; TAVARES, P.V.D.S.; SGRIGNOLI, S.S.; ANGELOCCI, L.V.; VIEIRA, J.M.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M. Study of a new formulation for a phosphorus-32 polymeric source for use in brachytherapy. Medical Physics, v. 51, n. 10, p. 7706-7706, 2024. DOI: 10.1002/mp.17457. Disponível em: https://repositorio.ipen.br/handle/123456789/49086. Acesso em: 13 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.