Stability evaluation of bandgel like hydrogel membranes

Abstract

Stability study of four types of similar to BandGel hydrogels which were crosslinked by ionizing radiation were carried out according to Agência Nacional de Vigilância Sanitária (ANVISA). This kind of assay is used to evaluate the formulation stability in the research and development of life care products as hygiene and cosmetics. The stability study provides some indications of product behavior in intervals of time at submitted environmental conditions from the fabrication to finished product validate date. By the stability profile it is possible to evaluate the performance, security and efficacy as well the acceptability of the product by the consumer. It was used cycles of 24h stored in an incubator at 40 + 2ºC and 24h stored in a refrigerator at 4 + 2ºC, during 4 weeks. After each week it was analyzed gel fraction and swelling properties. The results showed good stability of all hydrogel types with similar gel fraction and swelling compared with samples soon after prepared.