Resveratrol radiomodifier effect on Daphnia similis

Abstract

Resveratrol has beneficial properties as a potential antioxidant, protecting cells from free radicals, responsible for the natural aging process, anti-inflammatory action, acts against cardiovascular diseases in addition to showing a radiomodifying effect. Resveratrol is synthesized by a wide variety of plants in response to ultraviolet radiation or the action of certain pathogens. Due to the increasing use of this compound, due to its biological properties, studies are being carried out in the field of Ecotoxicology in order to provide information on the toxicity and radiomodifying effect of resveratrol for the development and adoption of criteria in order to improve environmental quality. It is known that resveratrol has radioprotective or radiosensitizing action, depending on its concentration. The objective of this study was to verify in which concentration resveratrol presents radioprotective effect. To achieve this goal, previous studies were carried out about the toxicity of resveratrol and gamma radiation effect on Daphnia similis to determine the lethal dose (LD50) of radiation and the EC50 (effective concentration) of resveratrol. Based on these data, the study of resveratrol radiomodifier effect on Daphnia similis demonstrated a higher resistance of this organism to gamma radiation at 55 Gy dose when previously exposed to resveratrol at concentrations of 6 and 7 μM, suggesting a radioprotective effect.