Compartmental and dosimetric studies of anti-CD20 labeled with sup(188)Re
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2016
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Journal of Radioanalytical and Nuclear Chemistry
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Radioimmunotherapy has the potential to deliver lethal radiation energy directly to malignant cells via
targeting of radioisotope-conjugated monoclonal antibodies (MAbs) to specific antigens. Rituximab (RTX) is
specifically targeted against CD20, a surface antigen
expressed by B-lymphocytes. The use of 188Re from a
188W/188Re generator system represents an alternative
radionuclide for therapy. Rhenium has chemical properties
similar to technetium and both can be conjugated to antibodies using similar chemistry methods. The objective of
this work is to prove the usefulness of this radiopharmaceutical based on dosimetric and pharmacokinetic studies
that are also required by the Brazilian Regulatory Agency.
Como referenciar
KURAMOTO, GRACIELA BARRIO; MATSUDA, MARGARETH M.N.; OSSO JUNIOR, JOAO A. Compartmental and dosimetric studies of anti-CD20 labeled with sup(188)Re. Journal of Radioanalytical and Nuclear Chemistry, v. 309, n. 3, p. 1029-1035, 2016. DOI: 10.1007/s10967-016-4703-y. Disponível em: http://repositorio.ipen.br/handle/123456789/26526. Acesso em: 19 Feb 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.