Nanocomposite polymer clay to support the release of drug
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2017
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Materials Science Forum
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It is estimated that there are about 300,00 products named biomaterials that are used in
the area of Health. Although they are widely used they have yet to be optimized for therapeutic use.
Hence, the objective of this work was to develop nanocomposites hydrogels with poly (vinyl
alcohol) (PVAl), glucantime, chitosan and synthetic clay Laponite RD, processed by gamma
irradiation. To compare the behavior of drug release two systems were compared, PVAl / chitosan /
clay and PVAl / clay. The morphology of the nanocomposites hydrogel was understood by using
characterization techniques: X-ray diffraction, scanning electron microscopy (SEM) and atomic
force microscopy (AFM) and gel fraction. The release kinetics was analyzed at 37 °C for period of
48 hours. It was observed that the slower release of the drug occurs in the delivery system
composed by PVAl / chitosan / clay with correlation of the crosslink type formed by chitosan.
Como referenciar
OLIVEIRA, MARIA J.A.; LUGAO, ADEMAR B.; PARRA, DUCLERC F. Nanocomposite polymer clay to support the release of drug. Materials Science Forum, v. 899, p. 335-340, 2017. DOI: 10.4028/www.scientific.net/MSF.899.335. Disponível em: http://repositorio.ipen.br/handle/123456789/28495. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.