Molecular damage
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2016
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Photodynamic therapy in veterinary medicine: from basics to clinical practice
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Photodynamic therapy (PDT) rapidly produces large amounts of reactive oxygen species (ROS) to induce death of photosensitized cells. As previously described in Chap. 2, excited photosensitizer (PS) molecules can either donate electrons (type 1) or energy (type 2) to ground-state oxygen to produce superoxide radicals (O2•−) or singlet oxygen (1O2). Each type of ROS has characteristic chemical reactivity and reacts with different types of chemical bonds present in biomolecules and, consequently, will lead to different types of cell damage. Once again, what determines the mechanism of cell death directly depends on both: the PS localization site within the cell and total extent of oxidative stress produced during therapy (i.e., light dosimetry and efficiency of ROS generation). To elucidate the mechanisms of photooxidative damage and the consequent biological effects, this chapter will cover the most relevant chemical reactions related to oxidative damage caused by 1O2 and free radicals.
Como referenciar
SABINO, CAETANO P.; HAMBLIN, MICHAEL R. Molecular damage. In: SELLERA, FABIO P. (ed.); NASCIMENTO, CRISTIANE L. (ed.); RIBEIRO, MARTHA S. (ed.). Photodynamic therapy in veterinary medicine: from basics to clinical practice. Gewerbestrasse, Switzerland: Springer, 2016. p. 45-56. DOI: 10.1007/978-3-319-45007-0_4. Disponível em: http://repositorio.ipen.br/handle/123456789/28659. Acesso em: 26 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.