New core configuration for producing Iodine 125 seeds
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2017
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Medical Physics
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Purpose: Cancer is one of the most complex public health problems. Prostate
cancer is the second most common among men. In prostate brachytherapy
use Iodine-125, which is fixated on a silver substrate, then inserted and
sealed in a titanium capsule. This work proposes a new source configuration
using epoxy resin substrate. Methods: Comparation and analysis methods
were used to define the methodology for combining iodine-125 in polymers.
The parameters were immersion time, reaction type, concentration of the
adsorption solution, specific activity of the radioactive solution, need for carrier and chemical form of radioactive iodine. Results: The methodology
developed with an epoxy resin was very good. The final radioactive intake on
the resin was higher than 80%. The immobilization of the radioactive solution
occurred in the matrix, without any loss or deposition of undesirable
materials on its surface, as evidenced by the smear test. The material maintains
its integrity when autoclaved at 140 °C. The curing process of the resin
was 40 minutes. With the value of the initial activity of the Iodine solution
by mass (774.2 lCi/g), it was possible to calculate the immobilization efficiency
Average of 680 lCi/g. The immersion test in distilled water at room
temperature did not exceed the limit allowed by ISO 9978, which is 5 nCi
(185 Bq), proof of no leakage. In a computational simulation by the Monte
Carlo Method, PENELOPE, the simulations were consistent with the values
adopted by the literature for the GE Healthcare model 6711, which shows the
value of the dose rate constant as 0, 965 cGy.U-1.h-1. Conclusion: The
effective method for combining iodine-125 in epoxy resin was determinated.
The major advantage was the high efficiency percentage fixation, around
82,1 3,2%, and the simplicity and safety of the process.
Como referenciar
RODRIGUES, B.T.; ROSTELATO, M.C.M.; SOUZA, C.D. de; ZEITUNI, C.; MOURA, E.S. de; SOUZA, D.B. de; TOZETTI, C.; RODRIGUES, B. New core configuration for producing Iodine 125 seeds. Medical Physics, v. 44, n. 6, p. 2828-2829, 2017. DOI: 10.1002/mp.12304. Disponível em: http://repositorio.ipen.br/handle/123456789/31135. Acesso em: 14 Mar 2025.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.