Degradation and toxicity of amoxicillin after electron beam irradiation
Carregando...
Data
2022
Data de publicação:
Autores IPEN
FLAVIO KIYOSHI TOMINAGA
DANIEL TEMPONI LEBRE
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
Brazilian Journal of Radiation Sciences
Exportar
Resumo
A recent and growing concern in environmental studies is the presence of antibiotics in wastewater, which contributes to antimicrobial resistance building. Amoxicillin, according to the World Health Organization, is one of the most consumed antibiotics worldwide, for being a first line therapy for common infections. Among several drug degradation methodologies, electron beam irradiation (EBI) is presented as an efficient and green treatment. This work presents data on amoxicillin degradation via EBI. Degradation rate was evaluated by LC/MS-MS, carbon removal efficiency was evaluated by TOC and ecotoxicity assays were performed employing Vibrio fischeri. Chromatographic results indicate an efficiency removal of 97.65% at 0.75 kGy and concentration below the limit of detection with increasing absorbed dose. Low mineralization (up to 10%) was achieved at 3.0 kGy. Regarding toxicity, approximately 81% of toxicity removal was obtained at 0.75 kGy and a decrease in efficiency was achieved with higher doses. In conclusion, results indicate the low doses (0.75 kGy) as most effective for drug removal employing EBI.
Como referenciar
BORRELY, S.I.; REDÍGOLO, M.M.; VILLARD, B.D.; LEBRE, D.T.; TOMINAGA, F.K. Degradation and toxicity of amoxicillin after electron beam irradiation. Brazilian Journal of Radiation Sciences, v. 10, n. 3B, p. 1-8, 2022. DOI: 10.15392/2319-0612.2022.1894. Disponível em: http://repositorio.ipen.br/handle/123456789/33499. Acesso em: 18 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.