JOSE DE SOUZA CALDEIRA FILHO
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Artigo IPEN-doc 09953 Development of biomolecules labelled with sup(177)Lu for cancer therapy2006 - ARAUJO, ELAINE B. de; MENGATTI, JAIR; BARBOZA, MARYCEL F. de; COLTURATO, MARIA T.; OSSO JUNIOR, JOAO A.; CALDEIRA FILHO, JOSE de S.; HERRERIAS, ROSANA; MURAMOTO, EMIKOCapítulo IPEN-doc 13639 Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy2007 - ARAUJO, E.B.; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.; OKASAKI, K.; SUZUKI, M.F.; GUIMARAES, M.I.C.C.The paper describes the methodology used for and the results of labelling [Tyr3 ]octreotate (TATE) with radioiodine (131I) and [DOTA,Tyr3 ]octreotate (DOTATATE) with 131I and lutetium (177Lu). The quality control and purification procedures are also described. Biodistribution studies were performed in normal Swiss mice and in nude mice bearing AR42J tumours. In vitro studies were used to evaluate the affinity of the radiopharmaceuticals for somatostatin receptors in rat brain cortex and tumour cells. Saturation binding and the internalization of the labelled peptides were determined. The frequency of micronuclei in peripheral blood lymphocytes exposed to different radioactive concentrations of [131I]DOTATATE and [ 177Lu]DOTATATE was evaluated by micronucleus assay.Artigo IPEN-doc 11424 Labeling of DOTA-Tyrsup(3)-octreotate with sup(177)Lu - stabillity and biodistribution study2005 - CALDEIRA FILHO, JOSE S.; MURAMOTO, EMIKO; SILVA, CONSTANCIA P.G.; ARAUJO, ELAINE B.Artigo IPEN-doc 14075 A comparative study of sup(131)I and sup(177)Lu labeled somatostatin analogues for therapy of neuroendocrine tumours2009 - ARAUJO, E.B. de; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.M.; PUJATTI, P.B.; SILVA, C.P.G.; MENGATTI, J.