JOSE DE SOUZA CALDEIRA FILHO
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Capítulo IPEN-doc 13639 Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy2007 - ARAUJO, E.B.; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.; OKASAKI, K.; SUZUKI, M.F.; GUIMARAES, M.I.C.C.The paper describes the methodology used for and the results of labelling [Tyr3 ]octreotate (TATE) with radioiodine (131I) and [DOTA,Tyr3 ]octreotate (DOTATATE) with 131I and lutetium (177Lu). The quality control and purification procedures are also described. Biodistribution studies were performed in normal Swiss mice and in nude mice bearing AR42J tumours. In vitro studies were used to evaluate the affinity of the radiopharmaceuticals for somatostatin receptors in rat brain cortex and tumour cells. Saturation binding and the internalization of the labelled peptides were determined. The frequency of micronuclei in peripheral blood lymphocytes exposed to different radioactive concentrations of [131I]DOTATATE and [ 177Lu]DOTATATE was evaluated by micronucleus assay.Resumo IPEN-doc 11816 Study of dosimetry and toxicity of 177Lu-DOTA-Y3-octreotate in rats2006 - GUIMARAES, MARIA I.C.C.; CALDEIRA, JOSE; NAGAMATI, LUCIO T.; BUCHPIGUEL, CARLOS A.; ARAUJO, ELAINE B.Artigo IPEN-doc 14075 A comparative study of sup(131)I and sup(177)Lu labeled somatostatin analogues for therapy of neuroendocrine tumours2009 - ARAUJO, E.B. de; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.M.; PUJATTI, P.B.; SILVA, C.P.G.; MENGATTI, J.