JOSE DE SOUZA CALDEIRA FILHO
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
Capítulo IPEN-doc 13639 Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy2007 - ARAUJO, E.B.; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.; OKASAKI, K.; SUZUKI, M.F.; GUIMARAES, M.I.C.C.The paper describes the methodology used for and the results of labelling [Tyr3 ]octreotate (TATE) with radioiodine (131I) and [DOTA,Tyr3 ]octreotate (DOTATATE) with 131I and lutetium (177Lu). The quality control and purification procedures are also described. Biodistribution studies were performed in normal Swiss mice and in nude mice bearing AR42J tumours. In vitro studies were used to evaluate the affinity of the radiopharmaceuticals for somatostatin receptors in rat brain cortex and tumour cells. Saturation binding and the internalization of the labelled peptides were determined. The frequency of micronuclei in peripheral blood lymphocytes exposed to different radioactive concentrations of [131I]DOTATATE and [ 177Lu]DOTATATE was evaluated by micronucleus assay.Artigo IPEN-doc 13234 Comparison of sup(131)I-TYRsup(3)-octreotate and sup(131)I-DOTA-TYRsup(3)Octreotate: the egffect of DOTA on pharmacokinetics and stability2005 - ARAUJO, E.B. de; MURAMOTO, E.; NAGAMATI, L.T.; CALDEIRA FILHO, J.S.; COUTO, R.M.; SILVA, C.P.G.Artigo IPEN-doc 11182 Radiolabeling and biodistribution of monoclonal antibody (MAb) anti-CD20 with iodine-1312005 - AKANJI, A.G.; MURAMOTO, E.; CALDEIRA FILHO, J.S.; COUTO, R.M.; ARAUJO, E.B.Artigo IPEN-doc 14075 A comparative study of sup(131)I and sup(177)Lu labeled somatostatin analogues for therapy of neuroendocrine tumours2009 - ARAUJO, E.B. de; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.M.; PUJATTI, P.B.; SILVA, C.P.G.; MENGATTI, J.