FABIANA DE ANDRADE BRINGEL
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Artigo IPEN-doc 28687 Sterilized human skin graft with a dose of 25 kGy provides a privileged immune and collagen microenvironment in the adhesion of Nude mice wounds2022 - MIRANDA, JURANDIR T. de; BRINGEL, FABIANA de A.; VELOSA, ANA P.P.; PROTOCEVICH, VERONICA; FERNEZLIAN, SANDRA de M.; SILVA, PEDRO L.; CAPELOZZI, VERA L.; MATHOR, MONICA B.; TEODORO, WALCY R.This study aimed to report the effects of different doses of ionizing radiation on inflammatory and repair stage of human skin graft adherence in Nude mice wounds. Animals were divided into transplanted with irradiated human skin grafts (IHSG) at 25 and 50 kGy (IHSG 25 kGy; IHSG 50 kGy) and non-IHSG and euthanized on the 3rd, 7th and 21st days after the surgery, by gross and microscopic changes, immunostaining for human type I collagen (Col I) and mouse Col I and Col III and inflammatory cells. We found an effectiveness of human split-thickness graft adherence in mice transplanted with IHSG 25 kGy, as well decrease in dermo-epidermal necrosis and neutrophils, lower loss of skin thickness, epithelization and neo-vascularization. Day 21 post-transplantation with IHSG 25 kGy was observed a well-preserved human skin in the border of the graft, a prominent granulation tissue in an organization by proliferated fibroblasts, Col III deposition and increased B-cells and macrophages. A complete adherence of human skin graft occurred with IHSG 25 kGy. We suggest that the ionizing radiation at 25 kGy mediates inflammation and the repair stage of human skin graft adherence in murine model, thus emerging as a potential tool in healing cutaneous wounds.Artigo IPEN-doc 21158 Qualitative and semi quantitative analysis in the healing area of athymic nude mice skin engrafted with human skin sterilized with gamma radiation2015 - MIRANDA, JURANDIR T. de; BRINGEL, FABIANA; ALVES, NELSON M.; ANTEBI, URI; FUNARI, ANA P.; MATHOR, MONICA B.Artigo IPEN-doc 16898 Imaging of irradiated human costal cartilage birefringence by PS-OCT2011 - MARTINHO JUNIOR, ANTONIO C.; FREITAS, ANDERSON Z.; SANTIN, STEFANY P.; SOARES, FERNANDO A.N.; MOSCA, RODRIGO C.; BRINGEL, FABIANA A.; MATHOR, MONICA B.Artigo IPEN-doc 17099 Comparison of techniques for morphologic evaluation of the repair process after transplantation of glycerol-preserved human skin subjected to gamma irradiation2011 - BRINGEL, FABIANA de A.; ISAAC, CESAR; HERSON, MARISA R.; FREITAS, ANDERSON Z. de; MARTINHO JUNIOR, ANTONIO C.; OLIVEIRA, SERGIO F. de; MATHOR, MONICA B.