CAROLINA BENETTI
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Artigo IPEN-doc 20857 Biochemical changes in cutaneous squamous cell carcinoma submitted to PDT using ATR-FTIR spectroscopy2015 - LIMA, CASSIO A.; GOULART, VIVIANE P.; CASTRO, PEDRO A.A. de; CORREA, LUCIANA; BENETTI, CAROLINA; ZEZELL, DENISE M.Nonmelanoma skin cancers are the most common form of malignancy in humans. Between the traditional treatment ways, the photodynamic therapy (PDT) is a promising alternative which is minimally invasive and do not requires surgical intervention or exposure to ionizing radiation. The understanding of the cascade of effects playing role in PDT is not fully understood, so that define and understand the biochemical events caused by photodynamic effect will hopefully result in designing better PDT protocols. In this study we investigated the potential of the FTIR spectroscopy to assess the biochemical changes caused by photodynamic therapy after 10 and 20 days of treatment using 5-aminolevulinic acid (ALA) as precursor of the photosensitizer photoporphyrin IX (PpIX). The amplitude values of second derivative from vibrational modes obtained with FTIR spectroscopy showed similar behavior with the morphological features observed in histopathological analysis, which showed active lesions even 20 days after PDT. Thus, the technique has the potential to be used to complement the investigation of the main biochemical changes that photodynamic therapy promotes in tissue.Resumo IPEN-doc 17465 Mechanisms of high intensity lasers for caries prevention and erosion2011 - ANA, P.A.; BACHMANN, L.; BENETTI, C.; GOULART, V.P.; ZEZELL, D.M.Resumo IPEN-doc 16035 FTIR spectroscopy monitoring chemical changes in enamel dentin and bone due to laser irradiation2010 - ZEZELL, DENISE M.; ANA, PATRICIA A.; BENETTI, CAROLINA; QUINTO JUNIOR, JOSE; PEREIRA, THIAGO M.; GOULART, VIVIANEResumo IPEN-doc 15314 Characterization by ATR-FTIR of irradiated bone2009 - BENETTI, C.; SANTOS, M.O.; GOULART, V.P.; ZEZELL, D.M.Resumo IPEN-doc 13507 Determinacao do limiar de ablacao o e coefeciente de absorcao o do osso para o laser de Er, Cr:YSGG2008 - BENETTI, CAROLINA; GOULART, VIVIANE P.; RAELE, MARCUS P.; FREITAS, ANDERSON Z. de; ZEZELL, DENISE M.Artigo IPEN-doc 15924 Composition and crystallographic changes on enamel when irradiated by Nd:YAG or Er,Cr:YSGG lasers and its resistance to demineralization when associated with fluoride2010 - ZEZELL, D.M.; ANA, P.A.; BENETTI, C.; GOULART, V.P.; BACHMANN, L.; TABCHOURY, C.P.M.; CURY, J.A.This study investigated the compositional and crystallographic changes on enamel when irradiated by Er,Cr:YSGG (λ=2.78µm, 8.5J/cm2 ) or Nd:YAG (λ=1064nm, 84.9J/cm2 associated with black coating), its resistance to demineralization when irradiation is associated with fluoride (APF-gel), and CaF2-like material formation and retention. Sample surfaces were analyzed by ATR-FTIR (4000–650cm-1, 4cm-1) resolution. Irradiation with Er,Cr:YSGG laser promoted a significant decrease on carbonate content of enamel. After Nd:YAG irradiation, it was observed a significant decrease of carbonate and amides I and II. X-ray diffraction showed that both laser irradiations promoted formation of α-tricalcium phosphate and tetracalcium phosphate, and a significant increase on the crystal growth of the enamel apatite (ANOVA, p<0.05 was used for all analysis). These changes can explain the improved resistance of enamel to demineralization observed in the second part of the study, in which 240 enamel slices were divided in 8 groups, received 4 min of professional fluoride gel (APF-gel 1.23%F- ) applied before or after irradiation. After treatments, the formation of calcium fluoride (CaF2) was determined. The remaining slabs of each group were submitted to a 10-day pH-cycling model and, subsequently, enamel demineralization was evaluated by cross-sectional microhardness. Both lasers significantly reduced enamel demineralization (ANOVA, p<0.05), and the previous APF-gel application followed by laser showed the higher reduction of enamel demineralization. CaF2 formed before pH-cycling was significantly higher in groups were APF was associated with laser irradiation. After demineralization, these groups also presented higher CaF2 retention in respect to isolated treatments (only APF or only laser), suggesting its anticaries potential.Resumo IPEN-doc 16401 FTIR spectroscopy monitoring chemical changes in enamel dentin and bone due to laser irradiation2010 - ZEZELL, DENISE M.; ANA, PATRICIA A.; BENETTI, CAROLINA; QUINTO JUNIOR, JOSE; PEREIRA, THIAGO M.; GOULART, VIVIANE