LUCAS VERDI ANGELOCCI

LUCAS VERDI ANGELOCCI

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A dosimetric evaluation using the Monte Carlo method considering geometric variations of the iodine-125 seed for brachytherapy
2024 - CHICO, H.S.; ANGELOCCI, L.V.; ZEITUNI, C.A.; SOUZA, C.D.; SGRIGNOLI, S.S.; ROSTELATO, M.E.C.M.
The Institute for Energy and Nuclear Research – IPEN-CNEN/SP is uniquely positioned to develop a new source of Iodine-125 for brachytherapy treatment. Therefore, research into the dosimetric process and source design is widely studied. Task Group 43 – TG 43 cites methodologies for dosimetry of sources for brachytherapy, the most used method is Monte Carlo. However, the dosimetric protocol does not mention possible variations in the source geometry after its conception. The investigative focus of the work was to obtain measurements of the Iodine-125 seed during the production stages until completion, quantify them and simulate them using the Monte Carlo method with the MCNP – 4C code, the formalism was in water and a 101x101 matrix was used to calculate the dose point by point. Two variations were chosen: a) seed length; b) nucleus length, using a batch of 100 seeds for each case. 100 simulations were carried out for each variation and one simulation using the reference seed geometry. The following calculations were applied: relative difference to compare variations to the reference; average among the 100 seeds of each batch to calculate the standard deviation. In both cases there was no point that exceeded 4.48% relative difference, and for standard deviation the largest point was 1.6%, while the Type A uncertainty was 0.018% at the largest point.
Estimation of dose deposition by 198-AuNPs in the prostate with MCNP in simplified geometry
2024 - SGRIGNOLI, S.S.; ANGELOCCI, L.V.; CHICO, H.S.; SOUZA, C.D.; BURIN, A.L.; RODRIGUES, P.S.; TEODORO, L.E.H.; MEDEIROS, I.M.M.; ZEITUNI, C.A.; ROSTELATO, M.E.C.M.
Development of a new material to encapsulate phosphorus-32 for use in brachytherapy
2022 - TEODORO, LARA E.H.; TALACIMON, CRISTHIAN F.; ROSERO, WILMMER A.A.; RIGO, MARIA E.Z.; RODRIGUES, PRISCILA S.; NOGUEIRA, THUANY C.; ANGELOCCI, LUCAS V.; ROSTELATO, MARIA E.C.M.
The term cancer refers to a set of malignant diseases that have in common the disordered growth of mutated cells, which can invade adjacent tissues or distant organs[1]. In 2020, cancer of the central nervous system (CNS) represented 1.6% of all new malignant tumor cases in the world, and about 2.5% of all new cancer deaths[2]. A promising radioactive source for use in intracavitary brachytherapy is phosphorus-32. This source has been prominent as a minimally invasive treatment for craniopharyngiomas and in the treatment of metastatic bone diseases in general[3]. To encapsulate phosphorus-32 and make it a viable radioactive source for use in medicine, some methods have emerged. In this work, we are developing a fabric soaked in industrial latex for this purpose, as this source comes in the form of orthophosphoric acid in aqueous solution and as industrial latex is soluble in water. Tests carried out so far show that the material supports orthophosphoric acid while is still malleable, which is essential for treating spinal cancer.
New model for an epoxy-based brachytherapy source to be used in spinal cancer treatment
2021 - SILVA, JOSE T.; SOUZA, CARLA D. de; ANGELOCCI, LUCAS V.; ROSERO, WILMMER A.A.; NOGUEIRA, BEATRIZ R.; CORREIA, RUANYTO W.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
The present work described the cold fabrication of a P-32 radioactive source to be used in CNS cancer using epoxy resin. The epoxy plaque fabricated with Teflon mold presented better agreement. MCNP simulation evaluated the radiation dose. Special attention was given to factors that can impact dose distribution. Average dose was 16.44 ± 2.89% cGy/s. Differences of less than 0.01 cm in thickness within the plaque lead to differences of up to 12% in the dose rate.
Monte Carlo simulation to assess free space and end-weld thickness variation effects on dose rate for a new Ir-192 brachytherapy source
2021 - ANGELOCCI, LUCAS V.; SOUZA, CARLA D. de; PANTELIS, EVAGGELOS; NOGUEIRA, BEATRIZ R.; ZEITUNI, CARLOS A.; ROSTELATO, MARIA E.C.M.
A new Iridium-192 seed for brachytherapy is under development. Specific dose rate contribution by two different factors were evaluated: the effect from movement of the core in the free space within the seed and the effect of the end-weld thickness variation. Both were investigated through use of the Monte Carlo radiation transport code MCNP6 and an in-house routine programmed with MATLAB. Differences greater than 15% compared to results from the nominal seed were found near the source, indicating a significant dose variation.