SAJID FAROOQ
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Artigo IPEN-doc 30501 Advances in metallic‑based localized surface plasmon sensors for enhanced tropical disease detection2024 - FAROOQ, SAJID; ZEZELL, DENISE M.Tropical diseases present significant challenges to global health, particularly in resource-limited regions. Early and accurate detection of these diseases is vital for effective management and control. In recent years, metallic-based LSPR sensors have emerged as promising diagnostic tools for sensitive and rapid detection of tropical diseases. This comprehensive review aims to provide an in-depth analysis of the current state of research on metallic-based LSPR sensors for the detection of various tropical diseases. In this study, we focused on the connection between neglected tropical diseases (NTDs) and its risk using metallic-based LSPR sensors to identify potential inflammatory biomarkers. We conducted a literature search using PubMed, Web of Science, and Google Scholar. Only published materials written in English were considered, resulting in the identification of 220 articles. After a comprehensive evaluation, we selected 35 relevant ones. Our analysis revealed 35 links to neglected tropical diseases, providing valuable insights into their relationship using metallic-based LSPR sensors. Moreover, we explore the potential of metallic-based LSPR sensors in point-of-care testing and their integration with emerging technologies such as microfluidics and smartphone-based diagnostics. This review underscores the need for continued research efforts to develop affordable, sensitive, and user-friendly metallic-based LSPR sensors for early detection and surveillance of tropical diseases.Artigo IPEN-doc 30236 Quantitative analysis of high performance plasmonic metamolecules for targeted deep tissues applications2023 - FAROOQ, SAJID; RATIVA, DIEGO; ARAUJO, RENATO E. deRationally designed gold nanoparticles (Au NPs) show a great potential for biomedical applications. Specifically, for optically induced heating of deep tissues facilitated by plasmonic-assisted lasers, nanostructures with high optical absorption coefficient in biological window are required. Plasmonic metamolecules, such as gold nanodimers (NDs), exhibit a robust localized field enhancement with strong infrared optical absorption. However, an exclusive investigation of the optical/ thermal features of high-performance Au NDs for optical infrared heating remains a challenge. Here, we focus on Au NDs for optothermal characteristics in deep tissues heating procedures. Our analysis encompasses parameters such as absorption cross-sections, field enhancement, and temperature rise with a systematic methodology selecting optimal NDs. Our findings reveal a non-uniform spatial distribution of temperature at the nano-scale and show that short-pulsed laser excitation enhances the temperature near the dimer’s junction. Remarkably, when compared to monomeric gold nanorods under the same excitation resonance mode, optically generated heating of Au NDs leads a threefold higher temperature increase. These results evidence valuable insights for using Au NDs as efficient plasmonic nanoheaters in photothermal-assisted applications.