RENATA MARTINUSSI COUTO
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Capítulo IPEN-doc 13639 Development of somatostatin based radiopharmaceuticals for receptor mediated radionuclide therapy2007 - ARAUJO, E.B.; CALDEIRA FILHO, J.S.; NAGAMATI, L.T.; MURAMOTO, E.; COLTURATO, M.T.; COUTO, R.; OKASAKI, K.; SUZUKI, M.F.; GUIMARAES, M.I.C.C.The paper describes the methodology used for and the results of labelling [Tyr3 ]octreotate (TATE) with radioiodine (131I) and [DOTA,Tyr3 ]octreotate (DOTATATE) with 131I and lutetium (177Lu). The quality control and purification procedures are also described. Biodistribution studies were performed in normal Swiss mice and in nude mice bearing AR42J tumours. In vitro studies were used to evaluate the affinity of the radiopharmaceuticals for somatostatin receptors in rat brain cortex and tumour cells. Saturation binding and the internalization of the labelled peptides were determined. The frequency of micronuclei in peripheral blood lymphocytes exposed to different radioactive concentrations of [131I]DOTATATE and [ 177Lu]DOTATATE was evaluated by micronucleus assay.Artigo IPEN-doc 15113 Standardization of methodology to derivatization and radiolabeling of the anti-CD20 monoclonal antibody from bifunctional chelator dota-nhs-ester2009 - MASSICANO, ADRIANA V.F.; AKANJI, AKINKUNMI G.; SANTOS, JOSEFINA S.; PUJATTI, PRISCILLA B.; COUTO, RENATA M.; MASSICANO, FELIPE; ARAUJO, ELAINE B.Resumo IPEN-doc 11825 Preparation of hidroxiapatite (90Y-HA) for synovectomy2006 - COUTO, R.M.; ARAUJO, E.B.; SOUZA, A.A.; MENGATTI, J.; BARBOZA, M.F.Resumo IPEN-doc 11824 Preparation of 90Y-citrate (90Y-CIT) for synovectomy2006 - COUTO, R.M.; ARAUJO, E.B.; SOUZA, A.A.; MENGATTI, J.; BARBOZA, M.F.